AJP 61 | Sjur Even Aunmo – fikk sparken for å snakke om bivirkninger

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Manage episode 329308990 series 2923822
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Allmennlege Sjur Even Aunmo fikk sparken som fastlegevikar fordi han fortalte pasienter at COVID-19-vaksinen kan gi bivirkninger. Dette er noe han plikter å gjøre ifølge Pasient- og brukerrettighetsloven § 4. Aunmo har satt seg grundig inn i forskningen på disse vaksinene, og påpeker at de for det første er eksperimentelle på dette stadiet. Videre er det Pfizer selv som har finansiert sin studie, en ansatt fikk sparken fordi hun varslet om at blindingen (anonymiseringen) var brutt, personer har blitt tatt ut av studien uten at det er oppgitt noen god grunn og rådataene for studien er ikke offentliggjort. Selv har han sett flere bivirkninger, som kraftige menstruasjonsblødninger, hjerteproblemer og alvorlige nevrologiske bivirkninger. Han frykter at underrapportering kan medføre at bivirkningstallene fra Statens legemiddelverk er for lave.
KILDER:
› COVID-19
https://clinicaltrials.gov/ct2/show/NCT04368728
https://clinicaltrials.gov/ct2/show/NCT04470427
Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
Efficacy of the mRNA-1273 SARS-CoV-2 Vaccine at Completion of Blinded Phase
https://covid-nma.com/vaccines/variants/
https://covid-nma.com/vaccines/index.php?search_by=1&search_input=1273&submit=Validate#moteur_recherche
How significant is the Ventavia scandal?
Covid-19: Researcher blows the whistle on data integrity issues in Pfizer's vaccine trial
CDC-vurdering av Modernas studie
https://www.bmj.com/company/newsroom/editors-call-for-covid-19-vaccine-and-treatment-data-to-be-available-for-public-scrutiny/
https://www.nrk.no/norge/norges-forste-koronavaksine-settes-1.15304159, lest 20.3.22
https://tidsskriftet.no/2021/05/originalartikkel/dodsfall-i-sykehjem-etter-covid-19-vaksine
https://www.fhi.no/hn/helseregistre-og-registre/dodsarsaksregisteret/tall-for-covid-19-assosierte-dodsfall-i-dodsarsaksregisteret-i-2020/
https://legemiddelverket.no/Documents/Bivirkninger%20og%20sikkerhet/Rapporter%20og%20oversikter/Koronavaksiner/20211028%20Rapport%20over%20meldte%20bivirkninger%20av%20koronavaksine.pdf
Surveillance for safety after immunization; vaccine adverse event reporting system (VAERS) - United States 1991-2001
Mandatory Reporting of Infectious Diseases by Clinicians
Myopericarditis after vaccination, Vaccine Adverse Event Reporting System (VAERS), 1990–2018
https://www.nrk.no/livsstil/_-en-medisinsk-katastrofe-1.10880384
https://legemiddelverket.no/nyheter/bivirkninger-av-vaksiner-hva-lerte-vi-av-pandemien-i-2009#ble-det-meldt-noen-d%C3%B8dsfall?
The illusion of evidence based medicine
Amerikanske Centers for Disease Control om underrapportering
Studie fra det medisinske tidsskriftet JAMA om underrapportering
Studie fra det medisinske tidsskriftet Vaccine om underrapportering
Fra det amerikanske registrerings-systemet VAERS om deres system
Randomised Clinical Trials of COVID-19 Vaccines: Do Adenovirus-Vector Vaccines Have Beneficial Non-Specific Effects?
‧ Lancet 2022. Samlestudie RCT. Obs: Preprrint, ikke fagfallevurdert enda. Signifikant og stor forskjell mellom Pfizer/Moderna og svekket-virus-vaksiner.
› FETT
Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis
Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73)
Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease
The effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials
Saturated Fats and Health: A Reassessment and Proposal for Food-Based Recommendations: JACC State-of-the-Art Review
http://dx.doi.org/10.1136/openhrt-2014-000196
Fat or fiction: the diet-heart hypothesis | BMJ Evidence-Based Medicine
https://www.mn.uio.no/ibv/tjenester/kunnskap/plantefys/leksikon/h/herdet-fett.html
4-Hydroxynonenal-Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease
https://doi.org/10.1016/j.freeradbiomed.2006.07.021
Dietary stearic acid regulates mitochondria in vivo in humans - Nature Communications
◦ 33.9 10.17140/AFTNSOJ-1-123 Oxidation of Polyunsaturated Fatty Acids and its Impact on Food Quality and Human Health
Dietary oxidized n-3 PUFA induce oxidative stress and inflammation: role of intestinal absorption of 4-HHE and reactivity in intestinal cells
Effect of the Type of Frying Culinary Fat on Volatile Compounds Isolated in Fried Pork Loin Chops by Using SPME-GC-MS
› STATINER
BMJ RCT sysrew/meta Statins for the primary prevention of cardiovascular disease: an overview of systematic reviews
The effect of statins on average survival in randomised trials, an analysis of end point postponement
JAMA RCT-meta 2010 - Statins and All-Cause Mortality in High-Risk Primary Prevention: A Meta-analysis of 11 Randomized Controlled Trials Involving 65 229 Participants
https://www.felleskatalogen.no/medisin/lipitor-upjohn-eesv-pfizer-560999
https://www.felleskatalogen.no/medisin/zocor-organon-565655
https://www.legemiddelhandboka.no/L8.15.1/Statiner
Statins - a call for transparent data - The BMJ
Statin Use and Risk of Diabetes Mellitus in Postmenopausal Women in the Women's Health Initiative
› KJØTT
Effect of Lower Versus Higher Red Meat Intake on Cardiometabolic and Cancer Outcomes A Systematic Review of Randomized Trials
Total red meat intake of ≥0.5 servings/d does not negatively influence cardiovascular disease risk factors: a systemically searched meta-analysis of randomized controlled trials
› KOLESTEROL
Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review
Inborn coagulation factors are more important cardiovascular risk factors than high LDL-cholesterol in familial hypercholesterolemia
• PMID: 18277343 ApoB/ApoA1 ratio and subclinical atherosclerosis
Cigarette smoking renders LDL susceptible to peroxidative modification and enhanced metabolism by macrophages
Cigarette Smoking Potentiates Endothelial Dysfunction of Forearm Resistance Vessels in Patients With Hypercholesterolemia: Role of Oxidized LDL
Passive Smoking Induces Atherogenic Changes in Low-Density Lipoprotein
Smoking and smoking cessation—The relationship between cardiovascular disease and lipoprotein metabolism: A review
Smoking and Cardiovascular Disease
LDL biochemical modifications: a link between atherosclerosis and aging
Association Between Circulating Oxidized LDL and Atherosclerotic Cardiovascular Disease: A Meta-analysis of Observational Studies
› KARBOHYDRAT
https://www.helsedirektoratet.no/rapporter/anbefalinger-om-kosthold-ernaering-og-fysisk-aktivitet/Anbefalinger%20om%20kosthold%20ern%C3%A6ring%20og%20fysisk%20aktivitet.pdf/_/attachment/inline/2f5d80b2-e0f7-4071-a2e5-3b080f99d37d:2aed64b5b986acd14764b3aa7fba3f3c48547d2d/Anbefalinger%20om%20kosthold%20ern%C3%A6ring%20og%20fysisk%20aktivitet.pdf
› DIABETES
JAMA WMI 2006Low-Fat Dietary Pattern and Risk of Cardiovascular DiseaseThe Women's Health Initiative Randomized Controlled Dietary Modification Trial – se side 661, økt hjerte/kar-risk sfa. Lavfett-diett
AmJourClinNutr WMI 2011 Effects of a low-fat dietary intervention on glucose, insulin, and insulin resistance in the Women's Health Initiative (WHI) Dietary Modification trial
AOCS Lipids (lavranket journal) Carbohydrate Restriction has a More Favorable Impact on the Metabolic Syndrome than a Low Fat Diet
Small Dense Low-Density Lipoprotein-Cholesterol Concentrations Predict Risk for Coronary Heart Disease- ArtThromVas prospektiv kohort
• Glycation as an atherogenic modification of LDL : Current Opinion in Lipidology
Glycosylated low density lipoprotein is more sensitive to oxidation: implications for the diabetic patient?
Loss of Endothelial Glycocalyx During Acute Hyperglycemia Coincides With Endothelial Dysfunction and Coagulation Activation In Vivo
› DIABETES-DEMENS
AgeingResearchRewiew 2019 sysrew/meta 144 prospektive studier – 58 % økt risiko demens
Int. Med. Journ. 2012 meta-analyse av prospektive kohorter dia-demens-risk 51 % økning demens
Lancet Neurology 2006, sysrew lavere evidensgrad. Risk of dementia in diabetes mellitus: a systematic review
Diabetes mellitus and the risk of dementia - The Rotterdam Study – prospektiv kohort
JDST 2008 Alzheimer's Disease is Type 3 Diabetes—Evidence Reviewed
MDPI 2015 Evaluating the Association between Diabetes, Cognitive Decline and Dementia
Ketone Bodies Promote Amyloid-β1–40 Clearance in a Human in Vitro Blood–Brain Barrier Model - 2020
Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implication - 2018
APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline - 2020
› HJERTE- OG KAR-SYKDOM
• 10.1001/jamacardio.2020.7073 Association of Lipid, Inflammatory, and Metabolic Biomarkers With Age at Onset for Incident Coronary Heart Disease in Women
› PLANTE-ANTINÆRINGSSTOFF OG VERN
Food Chemistry 2008 Bioaccessibility of Ca, Mg, Mn and Cu from whole grain tea-biscuits: Impact of proteins, phytic acid and polyphenols
Phytate in foods and significance for humans: food sources, intake, processing, bioavailability, protective role and analysis. Mol Nutr Food Res. 2009 Sep;53 Suppl 2:S330-75.
Oxalate content of foods and its effect on humans
Lectins as plant defense proteins
Effects of wheat germ agglutinin on human gastrointestinal epithelium: Insights from an experimental model of immune/epithelial cell interaction
Ingestion of subthreshold doses of environmental toxins induces ascending Parkinsonism in the rat
Identification of intact peanut lectin in peripheral venous blood
Do dietary lectins cause disease? BMJ
Lectin binding of endometrium in women with unexplained infertility
Changes in organs and tissues induced by feeding of purified kidney bean (Phaseolus vulgaris) lectins
Insecticidal Activity of Plant Lectins and Potential Application in Crop Protection
Bound Lectins that Mimic Insulin Produce Persistent Insulin-Like Activities
Contribution of leptin receptor N-linked glycans to leptin binding
Potato lectin activates basophils and mast cells of atopic subjects by its interaction with core chitobiose of cell-bound non-specific immunoglobulin E
<918::AID-IMMU918>3.0.CO;2-T Dietary lectins can induce in vitro release of IL-4 and IL-13 from human basophils
Secondary Oxalate Nephropathy: A Systematic Review
The effect of tea on iron absorption
• PMID: 1862 Disler PB, Lynch SR, Torrance JD, et al. The mechanism of the inhibition of iron absorption by tea. The South African Journal of Medical Sciences. 1975 ;40(4):109-116.
Effects of saponins and glycoalkaloids on the permeability and viability of mammalian intestinal cells and on the integrity of tissue preparationsin vitro
The biological action of saponins in animal systems: a review
Small Amounts of Gluten in Subjects With Suspected Nonceliac Gluten Sensitivity: A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial
◦ Obs: Kapsler brukt i studien ble supplert av legemiddelfirmaet Giuliani, som lager glutenfritt brød.
› LEKK TARM
Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines
Gliadin Induces an Increase in Intestinal Permeability and Zonulin Release by Binding to the Chemokine Receptor CXCR3
AmJourClinNu 2009 Cancer incidence in vegetarians: results from the European Prospective Investigation into Cancer and Nutrition (EPIC-Oxford)
FODMAP diet modulates visceral nociception by lipopolysaccharide-mediated intestinal inflammation and barrier dysfunction
• 73.3 10.12688/f1000research.20510.1 All disease begins in the (leaky) gut: role of zonulin-mediated gut permeability in the pathogenesis of some chronic inflammatory diseases
› LAVKARB
Effects of Low-Carbohydrate vs Low-Fat Diets on Weight Loss and Cardiovascular Risk Factors
BritJourNutr 2013 RCT-meta Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials
AnnIntMed 2004 A Low-Carbohydrate, Ketogenic Diet versus a Low-Fat Diet To Treat Obesity and Hyperlipidemia: A Randomized, Controlled Trial
JAMAIntMed A Randomized Trial of a Low-Carbohydrate Diet vs Orlistat Plus a Low-Fat Diet for Weight Loss
NEJM RCT 2006 A Low-Carbohydrate as Compared with a Low-Fat Diet in Severe Obesity
Short-term effects of severe dietary carbohydrate-restriction advice in Type 2 diabetes—a randomized controlled trial
Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: randomized trial
Effects of a low-carbohydrate diet on weight loss and cardiovascular risk factor in overweight adolescents
Comparison of the Atkins, Zone, Ornish, and LEARN Diets for Change in Weight and Related Risk Factors Among Overweight Premenopausal WomenThe A TO Z Weight Loss Study: A Randomized Trial
Efficacy and Safety of a High Protein, Low Carbohydrate Diet for Weight Loss in Severely Obese Adolescents
Long-Term Effects of a Novel Continuous Remote Care Intervention Including Nutritional Ketosis for the Management of Type 2 Diabetes: A 2-Year Non-randomized Clinical Trial
› FRUKTOSE
JourHepatology 2021 Fructose- and sucrose- but not glucose-sweetened beverages promote hepatic de novo lipogenesis: A randomized controlled trial
Effects of fructose restriction on liver steatosis (FRUITLESS); a double-blind randomized controlled trial
› KETOGENISITET/KREFT
https://oslo-universitetssykehus.no/behandlinger/pet-undersokelse
https://stanfordhealthcare.org/medical-tests/p/pet-scan/what-to-expect.html
https://www.sciencedirect.com/topics/medicine-and-dentistry/warburg-effect
The Warburg Effect: How Does it Benefit Cancer Cells?
NutrCanc 2019 Feasibility, Safety, and Beneficial Effects of MCT-Based Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Trial Study
Dietary Glycemic Load and Cancer Recurrence and Survival in Patients with Stage III Colon Cancer: Findings From CALGB 89803
Ketogenic diet in cancer therapy
› IATROGEN SKADE
https://tidsskriftet.no/2000/10/kronikk/uheldige-hendelser-i-helsetjenesten-forebygging-og-handtering
Opptaksdato: 2022-05-02
Publiseringsdato: 2022-05-22
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