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NR vs NMN is Dated, Boosting NAD+ to New Levels – EP21: Nichola Conlon (Nuchido)

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Why? Inaktiv feed status. Våre servere kunne ikke hente en gyldig podcast feed for en vedvarende periode.

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Manage episode 277457112 series 2416399
Innhold levert av Hyper Wellbeing Innovation Labs, Inc. and Hyper Wellbeing Innovation Labs. Alt podcastinnhold, inkludert episoder, grafikk og podcastbeskrivelser, lastes opp og leveres direkte av Hyper Wellbeing Innovation Labs, Inc. and Hyper Wellbeing Innovation Labs eller deres podcastplattformpartner. Hvis du tror at noen bruker det opphavsrettsbeskyttede verket ditt uten din tillatelse, kan du følge prosessen skissert her https://no.player.fm/legal.

In this twenty-first episode, Nichola Conlon provides a scientific background, introducing sirtuins and NAD. She then explains why popular NAD+ boosters, NR and NMN, are first-gen products.

Read the transcript

She details how Nuchido formulated the first second-gen product by taking a novel whole systems approach. Lots of NAD, anti-aging, and nutraceutical discussion along the way.

Topics we discussed in this episode
  • Recent personal experience with COVID-19
  • Her molecular biology PhD focus
  • Systems pharmacology
  • Help from Aubrey de Gray
  • Disillusioned with drug development
  • Founding Nuchido
  • What are Sirtuins? What is NAD?
  • Importance of NAD. Why Boost NAD Levels?
  • Inefficiency of First-Gen NAD Supplements: NR and NMN
  • Three ingredients to boost NAD
  • Pure NAD limitations
  • Nicotinamide Riboside (NR)
  • Nicotinamide Mononucleotide (NMN)
  • 60% increase in NAD “only”
  • Second-gen, demonstrated it can be done much better if you take a whole systems approach
  • Importance of NAD salvage pathway
  • PARP enzymes
  • Inability to power sustained high-levels because of salvage pathway deterioration
  • First-gen may not be great for epigenetics
  • Increases expression of the enzymes in the salvage pathway that are known to decline with age
  • Ingredients that reduce the expression of other processes that are actually wasting NAD
  • Enzyme called CD38
  • Inflammatory levels – CD38 just chews up NAD
  • Multiple things that you can do to fix the cell before you even need to put precursors in.
  • NAD decreases with age
  • Do we Need NAD Supplements?
  • Sirtuins and mitochondrial biogenesis
  • Boosting your NAD levels, improves mitochondrial function.
  • Multiple reasons that are causing the NAD to decline, boosting as with first-gen only the amount of raw material that your cell has is quite naïve
  • Second-gen helps fixe your body’s natural ability to make and recycle its own NAD
  • Nuchido TIME+ boosts NAD on average by 242%, four times more than the 60% widely cited for first-gen
  • ChromaDex vs Elyisum Health
  • Terms B3, niacin, nicotinamide, nicotinic acid, NR
  • Abram Hoffer and orthomolecular medicine
  • Nicotinamide is not likely to be a sirtuin inhibitor,
  • How to measure NAD levels
  • Nuchido TIME+ ingredients
  • Alpha lipoic acid (ALA) and effects on AMPK
  • Conversion of NADH to NAD+
  • Drift more towards having more NADH in your cell with age
  • Pathway called NQO1, converts NADH back to NAD+
  • ALA is a really powerful antioxidant, activates NRF2
  • ALA vs ALA-R
  • Sophora Japonica Extract Rutin, senolytic
  • NAMP
  • Aging is an inflicted cascade disorder
Show links
  continue reading

21 episoder

Artwork
iconDel
 

Arkivert serier ("Inaktiv feed" status)

When? This feed was archived on February 21, 2022 21:12 (2y ago). Last successful fetch was on November 14, 2020 00:02 (3+ y ago)

Why? Inaktiv feed status. Våre servere kunne ikke hente en gyldig podcast feed for en vedvarende periode.

What now? You might be able to find a more up-to-date version using the search function. This series will no longer be checked for updates. If you believe this to be in error, please check if the publisher's feed link below is valid and contact support to request the feed be restored or if you have any other concerns about this.

Manage episode 277457112 series 2416399
Innhold levert av Hyper Wellbeing Innovation Labs, Inc. and Hyper Wellbeing Innovation Labs. Alt podcastinnhold, inkludert episoder, grafikk og podcastbeskrivelser, lastes opp og leveres direkte av Hyper Wellbeing Innovation Labs, Inc. and Hyper Wellbeing Innovation Labs eller deres podcastplattformpartner. Hvis du tror at noen bruker det opphavsrettsbeskyttede verket ditt uten din tillatelse, kan du følge prosessen skissert her https://no.player.fm/legal.

In this twenty-first episode, Nichola Conlon provides a scientific background, introducing sirtuins and NAD. She then explains why popular NAD+ boosters, NR and NMN, are first-gen products.

Read the transcript

She details how Nuchido formulated the first second-gen product by taking a novel whole systems approach. Lots of NAD, anti-aging, and nutraceutical discussion along the way.

Topics we discussed in this episode
  • Recent personal experience with COVID-19
  • Her molecular biology PhD focus
  • Systems pharmacology
  • Help from Aubrey de Gray
  • Disillusioned with drug development
  • Founding Nuchido
  • What are Sirtuins? What is NAD?
  • Importance of NAD. Why Boost NAD Levels?
  • Inefficiency of First-Gen NAD Supplements: NR and NMN
  • Three ingredients to boost NAD
  • Pure NAD limitations
  • Nicotinamide Riboside (NR)
  • Nicotinamide Mononucleotide (NMN)
  • 60% increase in NAD “only”
  • Second-gen, demonstrated it can be done much better if you take a whole systems approach
  • Importance of NAD salvage pathway
  • PARP enzymes
  • Inability to power sustained high-levels because of salvage pathway deterioration
  • First-gen may not be great for epigenetics
  • Increases expression of the enzymes in the salvage pathway that are known to decline with age
  • Ingredients that reduce the expression of other processes that are actually wasting NAD
  • Enzyme called CD38
  • Inflammatory levels – CD38 just chews up NAD
  • Multiple things that you can do to fix the cell before you even need to put precursors in.
  • NAD decreases with age
  • Do we Need NAD Supplements?
  • Sirtuins and mitochondrial biogenesis
  • Boosting your NAD levels, improves mitochondrial function.
  • Multiple reasons that are causing the NAD to decline, boosting as with first-gen only the amount of raw material that your cell has is quite naïve
  • Second-gen helps fixe your body’s natural ability to make and recycle its own NAD
  • Nuchido TIME+ boosts NAD on average by 242%, four times more than the 60% widely cited for first-gen
  • ChromaDex vs Elyisum Health
  • Terms B3, niacin, nicotinamide, nicotinic acid, NR
  • Abram Hoffer and orthomolecular medicine
  • Nicotinamide is not likely to be a sirtuin inhibitor,
  • How to measure NAD levels
  • Nuchido TIME+ ingredients
  • Alpha lipoic acid (ALA) and effects on AMPK
  • Conversion of NADH to NAD+
  • Drift more towards having more NADH in your cell with age
  • Pathway called NQO1, converts NADH back to NAD+
  • ALA is a really powerful antioxidant, activates NRF2
  • ALA vs ALA-R
  • Sophora Japonica Extract Rutin, senolytic
  • NAMP
  • Aging is an inflicted cascade disorder
Show links
  continue reading

21 episoder

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