Evidence Based Medicine Podcaster

On this episode, Cole and I review some of the medications that gained U.S. FDA approval in 2023. We cover a variety of medications that treat various disease states. We focused more on outpatient medications and did not cover new oncology medication approvals. Cole and I are happy to share that our listeners can claim ACPE-accredited continuing ed…

In this audio summary, Alexander Wallace asks, in canine patients recovering from surgery for intervertebral disc disease, do passive range of motion exercises, compared to no intervention, lead to a shorter or faster rate of recovery? Read the full Knowledge Summary here. Audio Summaries are a free resource that enable vets and vet nurses to more …

On this episode, my good friend and colleague Alex Hovey, PA-C is sitting in for Cole this episode. We review the treatment of acute rhinosinusitis and pharyngitis. We mention some treatment options for symptom relief in patients with viral sinusitis and viral pharyngitis. We spend the majority of the episode covering the treatment algorithm for ba…

In this episode, Helen Silver-MacMahon talks to Pam Mosedale about Clinical Audit Awareness Week 2023, and how you can get involved by making a start on your own clinical audits. Read the transcript Learn more about Clinical Audit Awareness WeekAv RCVS Knowledge

On this episode we review post-traumatic stress disorder (PTSD). We discuss some background information on the disease. Then, we review the various treatment options used to manage PTSD symptoms. To finish the episode, we go through Dr. David N. Osser, MD's PTSD treatment algorithm. Dr. David N. Osser, MD is associate professor of psychiatry at Har…

On this episode, we discuss the 5-HT1A receptor agonist, Exxua (gepirone). Exxua was recently FDA approved for the treatment of general depression. We review the long road this medication took to get approved. We also summarize the dosing, adverse effects, drug-drug interactions, etc for Exxua. Thanks for listening! We want to give a big thanks to …

Sally Everitt speaks with Elly Russell and Julie Gibson about the paper 'Are They Thinking Differently? The Perceptions and Differences in Medical Disputes between Veterinarians and Clients'. Read the paper Read the podcast transcript Some further resources that are referenced in the podcast are linked below: Read the paper by Russell, E. et al (20…

In this VetTeamAMR podcast, Pam Mosedale speaks with Danny Chambers about the upcoming Antibiotic Amnesty. Danny touches on his experiences working in equine and small animal practice to discuss why the Antibiotic Amnesty is important, and how you can get involved. Get involved with the Antibiotic Amnesty campaign: https://knowledge.rcvs.org.uk/amr…

On this episode, we review the management of chronic kidney disease. We discuss when to use iron vs erythropoietin-stimulating agents (ESAs) for a patient with anemia due to their CKD. We also go over the management of metabolic acidosis, hyperphosphatemia, secondary hyperparathyroidism, etc. Cole and I are happy to share that our listeners can cla…

On this episode we discuss the management of benign prostatic hyperplasia (BPH) as well as overactive bladder (OAB). We review alpha blockers, 5-alpha-reductase inhihibitors, PDE5-inhibitors, anticholinergics, and beta 3 agonists. We close by discussing the best treatment options for patients with controlled BPH symptoms who are still experiencing …

On this episode, we review the treatment of both uncomplicated and complicated urinary tract infections (UTIs). We also use this episode to refresh some clinical pearls for the various antibiotics that are used when treating a UTI. Cole and I are happy to share that our listeners can claim ACPE-accredited continuing education for listening to this …

On this episdoe, we are joined by Dr. Alex Poppen, PharmD, the author of High Powered Medicine. HPM is a book that summarizes over 150 landmark clinical trials. We discuss how Alex came up with the idea for the book as well as how he got it published. We finish the episode with a quick review of the LoDoCo2 trial looking at colchicine for CV risk r…

Pam Mosedale speaks to 2023 Knowledge Award Antimicrobial Stewardship Champions Paul Stanley and Emily Parr from White Lodge Veterinary Surgery in Exmouth. They conducted a prospective audit to review antibiotic use in cat bite abscesses and successfully treated 86% of their patients without antibiotics without compromising patient welfare. Read th…

On this episode, we discuss both treating an acute gout flare and chronic management of gout. We discuss colchicine, NSAIDS, corticosteroids, canakinumab, xanthine oxidase inhibitors, uricosurics, URAT-1 inhibitor, and more. Cole and I are happy to share that our listeners can claim ACPE-accredited continuing education for listening to this podcast…

Richard and Raj discuss Palliative care

In this Audio Summary, Anne-Claude asks, in cats with psychogenic alopecia, is overgrooming reduced by the use of clomipramine compared to untreated cats? Read the full Knowledge Summary here. Audio Summaries are a free resource that enable vets and vet nurses to more quickly and more easily access and digest relevant and up-to-date evidence! A tim…

In this Audio Summary, Bonnie looks at whether lokivetmab is more effective than oclacitinib in reducing the Canine Atopic Dermatitis Lesion Index score (or some other recognised scoring system), in dogs with atopic skin disease. Read the full Knowledge Summary here. Audio Summaries are a free resource that enable vets and vet nurses to more quickl…

On this episode, we review pharmacotherapy options for managing osteoarthritis pain. We focus primarily on on hand, knee, and hip OA. We cover NSAIDS, COX2 inhibitors, topical capsaicin, intra-articular corticosteroids, intra-articular hyaluronic acid, duloxetine, and more. Cole and I are happy to share that our listeners can claim ACPE-accredited …

Sally Everitt speaks with Alex German, Professor of Small Animal Medicine at the University of Liverpool about the implications of his research into weight gain after neutering reported in the research paper entitled 'Comparison of growth in neutered Domestic Shorthair kittens with growth in sexually-intact Cats'. Read the paper Read the podcast tr…

Richard and Raj discuss some of the History of Statistics, and how it informs the practice of EBM today.

In this Audio Summary, Anna looks at whether dogs that are brachycephalic have an increased risk for developing heat-related illness compared to dogs that are not brachycephalics. Read the full Knowledge Summary here. Audio Summaries are a free resource that enables vets and vet nurses to access and digest relevant and up-to-date evidence quicker a…

On this episode, we review the medications that are FDA approved for weight loss. We also review recent data on high dose oral semaglutide and injectable tirzepatide. We end by looking at drugs that are currently in the pipeline with unique mechanisms of action. Cole and I are happy to share that our listeners can claim ACPE-accredited continuing e…

In this Audio Summary, Kristy looks at whether surgical treatment is more effective than nonsurgical therapy in reducing lumbosacral pain and neurological dysfunction in dogs suffering from degenerative lumbosacral stenosis (DLSS). Read the full Knowledge Summary here. Audio Summaries are a free resource that enables vets and vet nurses to access a…

Richard and Raj discuss how patients can be involved in the process of generating evidence, from determining patient centered outcomes to prioritizing types and goals of research.

On this episode, we are joined by Dr. Brian Gilbert, PharmD, BCCCP, FCCM, FNCS, to compare and contrast alteplase (tPA) versus tenecteplase (TNK-tPA) in the setting ischemic stroke. Brian is an emergency medicine clinical pharmacy specialist at Wesley Medical Center. He also serves as the PGY-2 critical care pharmacy residency program director and …

In this Knowledge Natter, Lou Northway speaks with David Charles, who was named a Knowledge Champion in the 2023 RCVS Knowledge Awards. David conducted an audit across multiple UK practices to gather data on ovine lambings and caesareans, and implemented training and recommendations related to the use of analgesia, antibiotics, and adjunctive medic…

On this episode, we review the management of hypothyroidism. We focus on levothyroxine as the foundation for a patient treatment. We also discuss the contraversial issue of using synthetic T3 (liothyronine) as an augmentation option for certain patients. The link to the Medscape article, Why the Hesitancy in Recommending Combination T3/T4 Therapy w…

In this Knowledge Natter, Lou Northway speaks Leanne McLeod from Earlswood Veterinary Hospital, who was named a Knowledge Champion in the 2023 RCVS Knowledge Awards. Leanne introduced a hypothermia audit that focused on pre-warming patients before general anaesthesia. By implementing new warming protocols, her team reduced the incidence of hypother…

On this episode, we discuss the various treatment options for community acquired pneumonia. We compare and contrast the differences in treating a patient with and without comorbidities in the outpatient setting as well as non-severe and severe CAP in the inpatient setting. We also review some basics for the various antibiotics used in CAP. Cole and…

Richard & Raj discuss decision making in EBM, and the tipping points that change clinical practice.

On this episode, we discuss the management of substance use disorder. We review the pharmacotherapy/psychotherapy options for treating the abuse of alcohol, cocaine, methamphetamine, cannabis, benzodiazepines, and opioids. Make sure to check out our previous episode that covers opioid use disorder specifically. Cole and I are happy to share that ou…

Richard & Raj discuss Overdiagnosis, starting with the difficulty of defining the term to the practical challenges in every day clinical practice. Links on Overdiagnosis: https://www.bmj.com/content/344/bmj.e3502 https://academic.oup.com/jnci/article/102/9/605/894608

Pam Mosedale speaks to VetTeamAMR Clinical Leads Angie Rayner and David Singleton about how the new initiative will provide companion animal veterinary teams with knowledge, resources and tools to make positive changes in their antimicrobial prescribing. VetTeamAMR for companion animal teams will launch at a free event on Tuesday 20 June. Sign up h…

In this podcast, Quality Improvement Clinical Lead Pam Mosedale talks to John Innes, honorary professor at Liverpool University, about new research that used data from RCVS Knowledge’s Canine Cruciate Registry (CCR) to determine its findings. The research provides estimates on the minimal clinically-important differences (MCIDs) for the two validat…

On this episode, we discuss the pharmacotherapy options available for smoking cessation. We start with some background info including pathophysiology, psychology models applicable to smoking cessation, and nicotine dependence assessments. We review varenicline, nicotine replacement therapy in various forms, bupropion SR, and others. Cole and I are …