ISCHEMIA trial hailed as practice changing The largest-ever RCT of initial invasive versus conservative management of stable ischemic heart disease makes waves. DAPA-HF: Dapagliflozin’s HFrEF efficacy confirmed in nondiabetics Further analyses from the DAPA-HF trial showed dapagliflozin cut death and heart failure events in HFrEF patients with no d…

Vascepa approved for cardiovascular risk reduction The FDA’s decision on cutting events in high-risk patients was based primarily on the REDUCE-IT trial. ENGAGE AF-TIMI: Insulin linked to greater risk for stroke, CV death, bleeding Novel oral anticoagulants may be preferred over warfarin in patients with diabetes and AFib. HHS drug importation prop…

Women have fewer cardiovascular events after non–ST-segment elevation ACS But they also remain undertreated with guideline-directed therapies. * * * Help us make this podcast better! Please take our short listener survey: https://www.surveymonkey.com/r/podcastsurveyOct2019 * * * FDA panel rejects vernakalant bid for AFib cardioversion indication El…

Icosapent ethyl cost effective in REDUCE-IT analysis Treatment with the fish-derived drug Vascepa for CV event reduction is more effective and less costly than placebo. * * * Help us make this podcast better! Please take our short listener survey: https://www.surveymonkey.com/r/podcastsurveyOct2019 * * * DAPA-HF: Dapagliflozin benefits regardless o…

This week’s Cardiocast is devoted entirely to Card Talk with cardiologist brothers Jim and Jerry Dwyer. They welcome two structural interventionalists at the Structural Heart and Valve Center at Emory Healthcare, Kendra J. Grubb, MD, and Isida Byku, MD. Both followed a unique track, training in both cardiac surgery and interventional cardiology and…

In this special meeting edition of the Cardiocast, MDedge Cardiology editor Catherine Hackett is joined by MDedge reporters Mitchel L. Zoler, Bruce Jancin, and Richard Mark Kirkner. The MDedge cardiology team reviews three big stories from the 2019 annual scientific sessions of the American Heart Association in Philadelphia. * * * Help us make this…

ISCHEMIA trial hailed as practice changing The largest-ever RCT of initial invasive versus conservative management of stable ischemic heart disease makes waves. * * * Help us make this podcast better! Please take our short listener survey: https://www.surveymonkey.com/r/podcastsurveyOct2019 * * * DAPA-HF: Dapagliflozin’s HFrEF efficacy confirmed in…

Getting high heightens stroke, arrhythmia risks Cannabis use or abuse among the young was associated with adverse cardiovascular consequences in two studies. * * * Help us make this podcast better! Please take our short listener survey: https://www.surveymonkey.com/r/podcastsurveyOct2019 * * * Bempedoic acid cuts LDL by 15% in patients with high le…

Closing the missing link between childhood risk factors and adult cardiovascular outcomes Prescient childhood cohort studies launched in the 1970s are paying off. * * * Help us make this podcast better! Please take our short listener survey: https://www.surveymonkey.com/r/podcastsurveyOct2019 * * * Metabolic signs of adult diabetes apparent in very…

Patients frequently drive too soon after ICD implantation Many patients didn’t recall ever receiving instruction about when to drive again. * * * Help us make this podcast better! Please take our short listener survey: https://www.surveymonkey.com/r/podcastsurveyOct2019 * * * One-third of CVD disease in blacks linked to hypertension A large analysi…

Strong showing for TAVR after 5 years in PARTNER 2ATranscatheter and surgical aortic valve replacement had similar rates of death or disabling stroke. * * * Help us make this podcast better! Please take our short listener survey: https://www.surveymonkey.com/r/podcastsurveyOct2019 * * * Patiromer allows more CKD patients to continue on spironolacto…

MDedge reporters discuss the latest in practice-changing data from the 2019 annual congress of the European Society of Cardiology in Paris. Join Mitchel L. Zoler, Bruce Jancin, Kari Oakes, and MDedge Cardiology editor Catherine Hackett as they discuss what they reported from the annual meeting.Av MDedge

Statin use linked to risk of skin and soft tissue infections Use of statins was associated with increased risk of SSTIs at an average of 91, 182, and 365 days. Rivaroxaban trends toward higher thrombotic risk than vitamin K antagonists in APS Patients who took rivaroxaban experienced almost two times as many thrombotic events as patients who took d…

Novel cardiac troponin protocol rapidly rules out MI Three-quarters of patients who presented with suspected acute coronary syndrome were safely discharged from ED without hospital admission. Study questions preemptive TEVAR for extended type A dissections Interim results from a single-center study show that preemptive TEVAR may not be necessary fo…

Smoking and inactivity are the most powerful lifestyle risk factors after an MI Insufficient activity beats out obesity or above-target LDL cholesterol. Ticagrelor monotherapy tops DAPT for high-risk PCI patients TWILIGHT findings support move to shorter dual-antiplatelet therapy. Panel releases guidelines for red meat, processed meat consumption "…

Cardiology dead last as women’s IM subspecialty choice Women in internal medicine residencies were more likely than men to report that they had never considered cardiology as a career choice. Beta-blockers effective, safe for HFrEF with renal dysfunction Their role is solidified for essentially all such heart failure patients, regardless of their r…

Prasugrel bests ticagrelor in ACS in surprise findings ISAR-REACT 5 was the first-ever direct head-to-head look at two potent P2Y12 inhibitors in this setting. European cholesterol guidelines push LDL targets below 55 mg/dL PCSK-9 inhibitors are elevated to a top-tier recommendation in very-high-risk patients. Drug doses for heart failure could pos…

MDedge reporters discuss the latest in practice-changing data from the 2019 annual congress of the European Society of Cardiology in Paris. Join Mitchel L. Zoler, Bruce Jancin, Kari Oakes, and MDedge Cardiology editor Catherine Hackett as they discuss what they reported from the annual meeting.Av MDedge

We introduce a brand new format with Jerome Dwyer, MD, brother of our host, Jim Dwyer, MD, for a new segment that we're calling 'Card Talk' where Dr. Jim and Dr. Jerry talk about the current clinical state of cardiology and take a peek into the future. This week in cardiology news: Survival at ‘overweight’ BMI surpasses ‘normal’Data from more than …

DAPA-HF results transform dapagliflozin from antidiabetic to heart failure drug Proof that dapagliflozin significantly helped heart failure patients without diabetes recategorizes the drug as a major agent for treating heart failure. New hypertension cases halved with community-wide salt substitution Social marketing principles achieved near-univer…

This week in cardiology: PCSK9 inhibition cuts events in very-high-risk groups ODYSSEY OUTCOMES analyses peg prior CABG and polyvascular disease as targets for alirocumab. Cardiovascular cost of smoking may last up to 25 years Past smokers face an elevated cardiovascular risk for up to 25 years after they quit. Impact of climate change on mortality…

TAVR valves now FDA approved for low-risk patients The FDA's decision will expand TAVR access to younger, healthier patients. FDA approves baroreflex activation for advanced HF A phase 4 trial will investigate impact on hospitalizations and mortality. Top line results: Dapagliflozin meets primary endpiont in DAPA-HF AstraZeneca announces preliminar…

The top news in cardiology: Midlife hypertension linked to dementia risk Elevated blood pressure in midlife is associated with risk of subsequent dementia, but whether the risk is treatable is unclear. Ambulatory BP slightly better than in-office measures for predicting cardiovascular outcomes It’s probably best to save these techniques for specifi…

The top stories in cardiology: Artificial intelligence technology meets AFib detection An AI-enabled ECG model suggests clinical implications for early identification of atrial fibrillation. Older patients who stop statins may be increasing their cardiovascular risk Discontinuation of statins was associated with an increased risk of hospital admiss…

The top news in cardiology: Meeting just 2 of 7 ‘simple’ goals lowers HF risk American Heart Association recommendations seem to lower risk even if only a couple of the 'Simple 7' are mastered. Increased cardiovascular risk seen early on with testosterone replacement therapy Testosterone replacement therapy for low testosterone is linked to an earl…

Statins crush early seizure risk poststroke Statin initiation upon hospitalization for acute ischemic stroke was linked to a major antiseizure benefit in a Japanese study. Atherosclerotic disease risk persists after smoking cessation Clinicians should reinforce smoking cessation with awareness that risk for several atherosclerotic diseases remains …

This week in cardiology: Systolic, diastolic BP each tied to adverse CV outcomes Diastolic hypertension can't be ignored, though systolic ultimately has a larger impact. Almost half of sudden cardiac deaths linked to prior silent MI Prior silent MIs were detected in nearly half of sudden cardiac deaths in people with no coronary artery disease. How…

The top stories in cardiology: New findings cast more doubt on fat-but-fit theory Patients who are obese and metabolically healthy face higher cardiac risk Higher omega-3 fatty acid levels cut heart failure risk A large multi-ethnic cohort study shows significantly higher levels of EPA in adults without heart failure. Microvascular disease: An inde…

This week's top stories in cardiology: Lipoprotein(a) levels, genes boost ischemic stroke risk Could some elderly skip statins based on negative risk markers? Cardiac events jump after COPD exacerbation CAROLINA findings reaffirm linagliptin’s safety, free glimepiride of CV-risk stigma You can contact the MDedge Cardiocast by emailing us at podcast…

This week's top stories in cardiology: FDA Panel: Continue using paclitaxel-eluting PAD Devices, with caveats. Although the benefits of the devices were clear, the panel felt there should be a label change to warn of the late mortality signal seen in a key meta-analysis. Many cardiac cath, electrophysiology lab directors receive big industry paymen…

This week's top stories in cardiology: Cognitive decline sped up after CHD Genetic analysis links PCSK9 inhibition and CV mortality Which antidiabetic for elderly patients? It depends on their CV risk Pivotal trial shows HFrEF benefits from baroreceptor stimulation You can contact the Cardiocast by emailing us at podcasts@mdedge.com or you can inte…

This week's top stories in Cardiology. Updated systematic review of aspirin primary prevention shows benefits, risks GLP-1 RA dulaglutide yields cardiac gains, even in non–at-risk patients DOACs surpass warfarin in low-weight AFib patients Medicaid expansion associated with lower cardiovascular mortality You can email the show at podcasts@mdedge.co…

You can find more of our podcasts at http://www.mdedge.com/podcasts This week in cardiology: FFR changes coronary management in one-third of patients MADIT-CHIC: CRT aids patients with chemotherapy-induced cardiomyopathy Lipoprotein(a) levels can guide CV risk assessment and treatment Cannabis: Doctors tell FDA to get out of the weeds Contact the s…

You can find more of our podcasts on our website at http://www.mdedge.com/podcasts. This week in cardiology: Novel cardiogenic shock, PCI protocol nets 72% acute survival Energy drinks increase BP and disrupt the heart's electrical activity Syncope during pregnancy increases risk for poor outcomes Ethnicity seems to affect predisposition to compone…

You can find more of our podcasts on our website: http://www.mdedge.com/podcasts This week in cardiology news: SCAI releases first definition of cardiogenic shock CABANA: Heart failure patients got biggest bang from AFib ablation Elderly concussion patients who used statins had lower dementia risk BMI in male teens predicts cardiomyopathy risk You …

Find more podcasts from MDedge on our website: https://www.mdedge.com/podcasts This week's top stories in cardiology: Risk score developed for cardiac-device infection AFib screening cuts hospitalizations and ED visits Arsenic exposure increases risk of left ventricular hypertrophy Ankylosing spondylitis patients taking COX-2 inhibitors may see few…

This week's top stories in clinical medicine: Single-center study outlines stoke risk, DOAC type in nonvalvular A-fib patients ACOG guidance addresses cardiac contributors to maternal mortality Higher serum leptin levels associated with PAD Employed physicians now outnumber independent doctors

This week's top stories in clinical cardiology: Long-term antibiotic use may heighten stroke, CHD risk Noninvasive FFRCT called ADVANCE in chest pain assessment Does BMI affect outcomes after ischemic stroke? Cardiac PET/CT can guise CAD therapy. You can contact the show by emailing us at podcasts@mdedge.com and you can follow us on Twitter at @MDe…

MDedge Cardiology editor Catherine Hackett hosts a conversation with Bruce Jancin and Mitch Zoler to talk about some of the research from the meeting as well as their general impressions. You can contact the show by emailing us at podcasts@mdedge.com.Av MDedge

This week in cardiology: Plant-based diet lowers risk of heart failure Medical societies endorse tiered certification for U.S. Heart-Valve care Ticagrelor doesn't beat clopidogrel in postfibrinolysis STEMI Cost gap widens between brand-name, generic drugs. You can contact the show at podcasts@mdedge.com…

This week in clinical cardiology. PCI reduces mortality after STEMI in older adults. Canagliflozin lowers kidney failure risk in T2D: CREDENCE. Poor response to statins hikes risk of cardiovascular events. Low LDL cholesterol may increase women’s risk of hemorrhagic strokeAv MDedge

This week in clinical cardiology: Alirocumab reduces both type 1 and 2 MIs. Despite failed primary endpoint, MI alert device has predictive value. Look for alcohol septal ablation in the next HOCM guideline. FDA: Forty ARBs free of nitrosamines. You can contact the Cardiocast with ideas, suggestions, stories, or questions for Dr. Dwyer by emailing …

This week's top stories in clinical cardiology: Has radial access PCI been overhyped? Hospital TAVR volume matters to patient survival. Studies link TMAO to microbiome, reveal new heart disease target. More chest compression–only CPR leads to increased survival rates. You can contact the show by emailing us at podcasts@mdedge.com or you can follow …

This week, a novel drug that reverses ticagrelor’s effect looks promising, a new certification process for cardiologists is unveiled, intensive blood pressure monitoring may not help prevent a second stroke, and the FDA cautions against using paclitaxel coated devices.

Cardiovascular prevention guidelines downgrade aspirin, high coronary artery calcium scores carry greater risks, an Apple Watch algorithm predicts AFib, and TAVR overtakes surgery in "historic" trials.

This week in MDedge Cardiocast: A novel drug lowers LDL in on top of maximums statins, invasive cardiology is a top money maker for hospitals, a meta-analysis parses the heart and kidney benefits of new diabetes drugs, and the AHA warns that heart-harming toxins may hurt hookah smokers.Av MDedge Cardiocsat

This week in MDedge Cardiocast: Infective endocarditis isn’t what it used to be, there’s a new, lower goal for Americans’ dietary intake of sodium, a drug to treat myeloma also raises heart failure risk, and Big Pharma says it can’t drop drug list prices alone.

The Food and Drug Administration could extend eligibility for Belviq to lower-risk patients, the agency says a popular gout drug raises cardiovascular risk, an AHA statement targets CV risk factors in children, and a class action suit against the American Board of Internal Medicine over MOC gets financial support from doctors.…

Silent strokes are common after noncardiac surgery, troubling news about nonadherence to statins, what cardiologists need to know about ARVC, and how gender inequality in medicine affects the health of all women.

This week in MDedge Cardiocast: Most tPA-eligible stroke patients now get treated within an hour, LAA closure can be treated safely in patients with prior hemorrhagic stroke, SGLT2 inhibitors are quickly morphing from diabetes to heart failure drugs, and the MESA cardiovascular disease risk calculator can be an improvement on the ACC/AHA version.…