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Concise summaries of everything published in the latest weekly issue of the New England Journal of Medicine (NEJM). NEJM publishes new medical research findings, review articles, and editorial opinion on topics of importance to biomedical science and clinical practice.
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NEJM AI Grand Rounds, hosted by Arjun (Raj) Manrai, Ph.D. and Andrew Beam, Ph.D., features informal conversations with a variety of unique experts exploring the deep issues at the intersection of artificial intelligence, machine learning, and medicine. You’ll learn how AI will change clinical practice and healthcare, how it will impact the patient experience, and about the people who are pushing for innovation. Whether you are an AI researcher or a practicing clinician, these conversations w ...
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Insightful conversations with leading experts in the field of health care, medical research, policy, and more from the New England Journal of Medicine (NEJM). Each episode examines the many complexities found at the junction of medicine and society.
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R. Alta Charo is a professor emerita of law and bioethics at the University of Wisconsin at Madison. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. R.A. Charo. Back to the Future in Alabama. N Engl J Med 2024;390:1253-1255.
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Featuring articles on alectinib in ALK-positive lung cancer, minimally invasive removal of cerebral hematomas, and CAR T-cell–mediated responses in recurrent glioblastoma; a review article on energy and macronutrients across the life span; a case report of a woman with falls and cognitive decline; a Medicine and Society on money as medicine; and Pe…
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In this episode of the AI Grand Rounds podcast, Dr. Eric Horvitz describes his career evolution from an interest in neurobiology to significant contributions in AI, particularly in understanding complex systems and applying AI in medicine. He discusses the shift from studying neurobiology to embracing AI and computational methods as tools for unrav…
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Featuring articles on omitting axillary dissection in breast cancer with sentinel-node metastasis, a trial of lixisenatide in early Parkinson’s disease, nirmatrelvir–ritonavir in outpatients with Covid-19, and hospitalization for chronic kidney disease; a review article on the prevention of cardiovascular disease in type 1 diabetes; a case report o…
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Daniel Sulmasy is director of the Kennedy Institute of Ethics and a professor in the Departments of Medicine and Philosophy at Georgetown University. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. D.P. Sulmasy. Physicians, Spirituality, and Compassionate Patient Care. N Engl J Med 2024;390:1061-1063.…
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Featuring articles on autism and prenatal exposure to antiseizure medication, ribociclib plus endocrine therapy in early breast cancer, gene therapy for giant axonal neuropathy, and anti–interleukin-23 in immunodeficiency; a review article on wearable digital health technologies in clinical care; a case report of a man with a fall; and Perspective …
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Dhruv Khullar is an assistant professor of medicine and of population health sciences at Weill Cornell Medicine. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. D. Khullar, L.P. Casalino, and A.M. Bond. Vertical Integration and the Transformation of American Medicine. N Engl J Med 2024;390:965-967.…
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Featuring articles on a blood-based test for colorectal cancer screening, a multitarget stool DNA test for colorectal cancer, iptacopan for paroxysmal nocturnal hemoglobinuria, and preterm birth and other outcomes of maternal RSV vaccination; a review article on cerebral cavernous malformations; a case report of a man with cardiac arrest, cardiogen…
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Featuring articles on an antibody–drug conjugate in untreated urothelial cancer, omalizumab for multiple food allergies, microplastics and nanoplastics in carotid plaque, and benralizumab or mepolizumab for eosinophilic granulomatosis with polyangiitis; a review article on the health effects of endocrine-disrupting chemicals; a Clinical Problem-Sol…
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José Rodríguez is a tenured professor in the Department of Family and Preventive Medicine and the associate vice president for health equity, diversity, and inclusion at University of Utah Health. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. J.E. Rodríguez and K. Stoesser. Transforming Diversity of a Family M…
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Featuring articles on a trial of seladelpar in primary biliary cholangitis, a trial of elafibranor in primary biliary cholangitis, cognition and memory after Covid-19, and simple versus radical hysterectomy in women with low-risk cervical cancer; a review article on cardiac rehabilitation; a case report of a woman with alternating sixth cranial ner…
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Ilya Golovaty is an acting assistant professor of medicine at the University of Washington. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. I. Golovaty and S. Hagan. Direct-to-Consumer Platforms for New Antiobesity Medications — Concerns and Potential Opportunities. N Engl J Med 2024;390:677-680.…
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Featuring articles on CD19 CAR T-cell therapy in autoimmune disease, tenecteplase for stroke at 4.5 to 24 hours, biomarker changes in years before Alzheimer’s disease, and a hepcidin mimetic in polycythemia vera; a review article on wearable digital health technologies for epilepsy; a case report of a man with fatigue and night sweats; and Perspect…
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In this episode of the AI Grand Rounds podcast, Dr. James Zou shares his personal journey to discovering machine learning during his graduate studies at Harvard. Fascinated by the potential of AI and its application to genomics and medicine, Dr. Zou embarked on a journey that took him from journalism to the forefront of AI research. He has been ins…
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Dave Chokshi is a professor at the Colin Powell School for Civic and Global Leadership at the City College of New York and a physician at Bellevue Hospital. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. D.A. Chokshi and F.P. Cerise. Ethical Issues in Providing Care in Safety-Net Health Systems. N Engl J Med 20…
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Featuring articles on frexalimab in multiple sclerosis, e-cigarettes for smoking cessation, cefepime–taniborbactam for complicated UTI, and the treatment of Wolman’s disease in an infant; review articles on treatment-resistant depression in older adults and on Behçet’s syndrome; a case report of a man with fevers; and Perspective articles on ethica…
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David Higgins is a research fellow and investigator at the Adult and Child Center for Outcomes Research and Delivery Science and a general academic pediatrician in the Department of Pediatrics at the University of Colorado School of Medicine and Children’s Hospital Colorado. Stephen Morrissey, the interviewer, is the Executive Managing Editor of th…
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Featuring articles on a phase 3 trial of resmetirom in NASH with liver fibrosis, an interleukin-23–receptor antagonist for plaque psoriasis, the neurovascular complications of F. solani meningitis, and on ocular gene therapy; a review article on coccidioidomycosis and histoplasmosis; a case report of a man with fever and headache after internationa…
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Featuring articles on an attenuated tetravalent dengue vaccine, skin antisepsis before fracture surgery, N-acetyl-l-leucine in Niemann–Pick Disease type C, in vivo CRISPR-Cas9 treatment for hereditary angioedema, and on seeing medicine more as a job than a calling; a review article on cardiac implantable electronic devices; a Clinical Problem-Solvi…
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Andrew Lea is a resident physician in internal medicine at Brigham and Women’s Hospital and a clinical fellow at Harvard Medical School. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. A.S. Lea and D.S. Jones. Mind the Gap — Machine Learning, Dataset Shift, and History in the Age of Clinical Algorithms. N Engl J…
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Featuring articles on daratumumab in myeloma therapy, the early treatment of patent ductus arteriosus with ibuprofen, measurable residual disease in chronic lymphocytic leukemia, hospital prices for physician-administered drugs, and on Asian Americans and racial justice in medicine; a review article on wearable technologies in cardiovascular medici…
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Thomas Gallagher is a professor in the Department of Medicine and the Department of Bioethics and Humanities at the University of Washington. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. T.H. Gallagher and A. Kachalia. Responding to Medical Errors — Implementing the Modern Ethical Paradigm. N Engl J Med 2024;…
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Featuring articles on testosterone treatment and fractures in men, long-term resynchronization–defibrillation therapy for heart failure, azithromycin to prevent infant mortality in Burkina Faso, oral simnotrelvir for adult patients with Covid-19, understanding liability risk from health care AI tools, and the rise of house staff unions; a review ar…
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In this episode of the AI Grand Rounds podcast, Dr. Roxana Daneshjou shares her journey from a childhood influenced by early exposure to science to her current role as an assistant professor at Stanford. Her path includes a critical shift during medical school, where her interest in computational methods and human genomics led her to pursue both an…
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Joseph Friedman is a medical student at the David Geffen School of Medicine at UCLA who has a Ph.D. in social medicine. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. J. Friedman and S.E. Hadland. The Overdose Crisis among U.S. Adolescents. N Engl J Med 2024;390:97-100.…
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In this episode, Dr. Zak Kohane shares his journey into AI and medicine, reflecting on early influences from science fiction authors and programming experiences in his youth. He discusses his academic path, moving from programming and machine instruction to medical school, driven partly by practical advice and personal ambition. Kohane highlights h…
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Crystal Cené is chief administrative officer for health justice, equity, diversity, and inclusion and associate chief medical officer for health equity at UC San Diego Health, a professor of clinical medicine at the University of California, San Diego, and a member of the Journal’s Perspective Advisory Board. Stephen Morrissey, the interviewer, is …
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