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Rheumatology is an incredibly fast-moving and exciting field of medicine that can be difficult to keep up with. This podcast provides busy clinicians with quick updates in the field of autoimmunity, with emphasis on new medications, treatment guidelines and explorations into the pathophysiology of diseases. The show will also feature historical perspectives in the field of rheumatology, as well as fascinating case presentations of medical mysteries complete with discussions from experts in t ...
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In this edition, screening program identifies airways disease in previously undiagnosed COPD, positive results show benefits of subcutaneous bispecifics and more. Read the full coverage here: Lung cancer screening program identifies airways disease in previously undiagnosed COPD Positive results in lung cancer show benefits of subcutaneous bispecif…
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In this edition, AI model helps predict anti-VEGF response in DME, Merck to acquire EyeBio and more. Read the full coverage here: VIDEO: AI model helps predict anti-VEGF response in diabetic macular edema Merck to acquire EyeBio VIDEO: IOP remains stable up to 48 weeks with aflibercept 8 mg for DME Phase 2 study of potential DME oral therapy meets …
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In this edition, difficult-to-treat psoriatic arthritis 'not all about the therapies', Samsung biosimilar comparable to etanercept and more. Read the full coverage here: Difficult-to-treat psoriatic arthritis 'not all about the therapies' Samsung biosimilar comparable to etanercept for psoriatic arthritis outcomes at 1 year Boehringer Ingelheim, Qu…
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Humans have had an insatiable appetite for inhibiting production of prostaglandins for centuries! This series delves into the history of aspirin and NSAIDs, looking at the understanding of the prostaglandin pathway. · Intro 0:12 · In this episode 0:23 · What are NSAIDs? 0:53 · Prostaglandins 5:50 · What are prostaglandins? 7:19 · Where do prostagla…
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In this edition, smoking cessation support uptake at lung cancer screenings, glecirasib may deliver ‘efficacy and tolerability advantages’ and more. Read the full coverage here: Uptake of smoking cessation support high when offered at lung cancer screening Glecirasib may deliver ‘efficacy and tolerability advantages’ for KRAS-mutant lung cancer ‘Su…
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In this edition, FDA accepts new drug application for Eluminex, most mentors in vitreoretinal subspecialty are men and more. Read the full coverage here: FDA accepts investigational new drug application for Eluminex DME treatment Most mentors in vitreoretinal subspecialty are men Carotid artery stenosis linked to retinal changes in patients with di…
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In this edition, FDA approves Selarsdi as Stelara biosimilar, deucravacitinib improves ‘broad range’ of patient-reported outcomes and more. Read the full coverage here: FDA approves Selarsdi as Stelara biosimilar for psoriasis, psoriatic arthritis Deucravacitinib improves ‘broad range’ of patient-reported psoriatic arthritis outcomes Advanced thera…
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In this edition, durvalumab improves survival in limited-stage small cell lung cancer, most adults do not test homes for radon exposure and more. Read the full coverage here: Durvalumab improves survival in limited-stage small cell lung cancer Survey: Most adults do not test homes for radon exposure, unconcerned about risks FDA fast tracks investig…
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This episode digs into the pathophysiology of urticaria vasculitis from anti-C1q to the story of bradykinin. · Intro 0:11 · In this episode 0:22 · Review of episode 83 1:23 · Listen to previous episode, The Complement System for Dunces 4:09 · Anti-C1q antibodies 6:26 · Lupus, anti-C1q and lupus nephritis 9:33 · What happens when you inject anti-C1q…
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In this edition, PALADIN study navigates IOP-lowering surgery in DME patients, small-molecule eye drop well-tolerated as treatment for retinal vascular diseases and more. Read the full coverage here: PALADIN study: Navigating IOP-lowering surgery in DME patients for optimal outcomes Small-molecule eye drop safe, well-tolerated as treatment for reti…
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In this edition, race identified as risk factor for VTE, FDA approves Rybrevant for treatment of non-small cell lung cancer and more. Read the full coverage here: Race identified as risk factor for VTE after pulmonary resection for lung cancer FDA approves Rybrevant for treatment of non-small cell lung cancer Behavioral health disorders have a ‘big…
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Is it an allergy or an autoimmune vasculitis, or a little of both? Find out the story of urticarial vasculitis, how this disease was recognized and eventually sorted out from other types of urticaria. · Intro 0:12 · In this episode 0:21 · Case study 1:22 · Chronic spontaneous urticaria, hives and nettles 7:57 · Dermatographism and witchcraft? 10:15…
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In this edition, blood test for lung cancer patients who may benefit from further immunotherapy, invasive procedures following lung cancer screenings and more. Read the full coverage here: Blood test identifies those with lung cancer who may benefit from further immunotherapy Invasive procedures rarely follow false-positive lung cancer screenings S…
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In this edition, FDA places hold on cell therapy trial after patient death, selpercatinib delivers superior outcomes and more. Read the full coverage here: FDA places hold on trial of cell therapy for lung cancer after patient death Selpercatinib delivers superior outcomes, may ‘reduce the burden of NSCLC’ First-line immunotherapy benefits patients…
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What should rheumatologists know about what we've learned about COVID-19 and long COVID in 2023? Hosted by Dr. Leonard Calabrese. · Intro 0:11 · In this episode 0:21 · 2023: current status and controversies 0:35 · What is going on with COVID-19? 01:53 · What do we know about vaccine responses? What should we be telling our patients about vaccines i…
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In this edition, an advocacy group petitions the FDA for stronger safety warnings for Botox, melanoma regression is associated with improved prognosis and more. Read the full coverage here: Advocacy group petitions FDA for stronger safety warnings for Botox, related drugs Melanoma regression associated with improved prognosis Phase 4 results show V…
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It's that time of year again, everyone rolling up their sleeves to get a flu shot. This episode dives into the history of the struggles pinning down the causative agent of flu and the journey to the vaccine! · Intro 0:12 · In this episode 0:17 · The history of the flu: 1892 3:10 · Rabies and dead virus 10:52 · A Sickness in the Serum, Part 2 14:31 …
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In this edition, allergic illnesses in children may be inherited from mothers; addressing needs of Muslim patients in dermatology; YouTube content on topical steroid withdrawal exhibits poor reliability and more. Read the full coverage here: Atopic dermatitis, other allergic illnesses in children may be inherited from mothers Addressing needs of Mu…
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In this edition, dermatologists ‘uniquely positioned’ to aid human trafficking victims; FDA approves Cosentyx for hidradenitis suppurativa and more. Read the full coverage here: Dermatologists ‘uniquely positioned’ to recognize, aid human trafficking victims FDA approves Cosentyx as first IL-17A inhibitor for hidradenitis suppurativa FDA approves S…
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What is silica? How does it impact your risk of developing autoimmunity if you inhale it, inject it or even snort it up your nose? Listen and find out! · Intro 0:12 · In the previous episodes 0:28 · The Ajax incident of 1979 1:15 · Silica and its association with autoimmune disease 4:11 · The history of silica and the health risks 5:21 · Rheumatoid…
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In this edition, multicancer detection tests show promise; lifestyle counseling appointments benefit cancer survivors; use of low-value drugs for patients with cancer, and more. Read the full coverage here: Multicancer detection tests show promise, but questions linger about their accessibility Shared medical appointments for lifestyle counseling b…
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In this edition, FDA approves Bimzelx for plaque psoriasis; roflumilast foam improves quality of life in patients with seborrheic dermatitis and more. Read the full coverage here: FDA approves Bimzelx for treatment of moderate to severe plaque psoriasis Roflumilast foam improves quality of life in patients with seborrheic dermatitis Opzelura effect…
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In this episode, we dig through the data of lupus in Africa and speak with experts on the Lupus Gradient, the impact of malaria and what we can learn from it all. · Intro 0:12 · In the previous episode 0:30 · Lupus Gradient 2:01 · Back to Dr. Brian Greenwood 3:48 · Polyarthritis 4:04 · Rates of autoimmune diseases 6:00 · Malaria and mouse models 7:…
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In this edition, FDA issues complete response letter for relabotulinumtoxinA; mucocutaneous manifestations may signal COVID-induced inflammatory disease in children and more. Read the full coverage here: FDA issues complete response letter for relabotulinumtoxinA for frown lines, crow’s feet Mucocutaneous manifestations may signal COVID-induced inf…
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In this edition, precision navigators reduce racial disparities in genomic testing; cancer diagnoses fell sharply during early days of pandemic; Prostate Cancer Awareness Month updates, and more. Read the full coverage here: Precision navigators reduce racial disparities in genomic testing for prostate cancer Cancer diagnoses fell sharply during ea…
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In this edition, retinoids and OTC products for photoaged skin; fractional lasers show promise in skin cancer prevention; a botanical drug for severe thermal burns and more. Read the full coverage here: Prescription retinoids, OTC products positively impact photoaged skin Fractional lasers show promise in skin cancer prevention Botanical drug may o…
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In this edition, CDC issues a health advisory concerning flesh-eating bacterium, staging for melanoma does not represent accurate recurrence and mortality and more. Read the full coverage here: CDC issues health advisory about recent reports of fatal Vibrio vulnificus Study finds melanoma treatment costs have increased, but so has survival Melanoma…
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In this edition, nearly $1 million in grants to aid diversity, equity, inclusion research; topical halcinonide may benefit patients with psoriasis; Asian patients may experience earlier mycosis fungoides diagnosis and more. Read the full coverage here: Nearly $1 million in grants to aid dermatology research in diversity, equity, inclusion Topical h…
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In this edition, ‘equitable access’ to care may reduce racial disparities in survival; exercise may improve sexual function among men with prostate cancer; image-guided adaptive prostate radiation therapy for short-term toxicities, and more. Read the full coverage here: ‘Equitable access’ to care may reduce racial disparities in prostate cancer sur…
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In this edition, M-PDT efficacy similar to isotretinoin in acne vulgaris; Spitz neoplasm diagnosis in adults; immunotherapy treatment shows promise in basal cell carcinoma and more. Read the full coverage here: M-PDT efficacy similar to isotretinoin in acne vulgaris Clinicians should not ‘shy away’ from a Spitz neoplasm diagnosis in adults Novel no…
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This episode delves into what we can learn about the impact of the environment on autoimmunity, digging into how rates of autoimmunity can vary drastically in different parts of the world. · Intro 0:12 · In this episode 0:16 · Dr. Brian Greenwood 0:22 · The geography of autoimmunity 7:01 · Type 1 diabetes 10:31 · Finland and type 1 diabetes 13:57 ·…
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In this edition, nonalcoholic muscadine wine may improve aging skin; atopic disease risk increases in sexually diverse patients; AI doubles diagnostic accuracy among patients with skin of color and more. Read the full coverage here: Nonalcoholic muscadine wine may improve aging skin in older women Atopic disease risk increases in sexually diverse p…
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In this edition, FDA approves Vanflyta for newly diagnosed AML; liso-cel could have ‘best shot’ at remission for double refractory CLL; mortality factors among cancer survivors and more. Read the full coverage here: FDA approves Vanflyta for newly diagnosed acute myeloid leukemia VIDEO: Liso-cel could have ‘best shot’ at remission for double refrac…
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In this edition, lack of sunless tanner education may cause confusion; intralesional HPV vaccine may clear recalcitrant warts; Ilumetri improves well-being of patients with plaque psoriasis and more. Read the full coverage here: Lack of sunless tanner education may cause diagnostic confusion, UV exposure Intralesional HPV vaccine may clear recalcit…
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In this edition, obesity linked to adverse outcomes among AYAs; pirtobrutinib produces high response rates; CDC study reveals overall increase in pediatric cancer incidence and more. Read the full coverage here: Overweight, obesity linked to adverse outcomes among AYAs treated for leukemia Pirtobrutinib produces high response rates in heavily pretr…
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In this edition, novel serum improves hair growth in androgenetic alopecia; cardiovascular disease linked to dermatological inflammatory diseases; sugary drinks may be associated with male pattern hair loss and more. Read the full coverage here: Novel serum improves hair growth in androgenetic alopecia with no side effects Cardiovascular disease as…
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This episode delves into the history of the hygiene hypothesis. What do we know about different exposures changing risk for asthma and allergies, and do these exposures have the same protection for autoimmunity? · Intro 0:12 · In this episode 0:18 · Hygiene hypothesis 0:33 · Allergic rhinitis (or Hay fever) 2:32 · Pollen and the allergy skin test 8…
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In this edition, CAR-T trial for leukemia paused after patient death; obesity may increase risk for blood cancer; new CAR T-cell therapies ‘waiting’ for patients with leukemia and more. Read the full coverage here: Seattle Children’s pauses trial of CAR-T for leukemia after patient death Obesity may increase risk for blood cancer VIDEO: New CAR T-c…
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In this edition, Leqembi shows benefits in early Alzheimer’s, sex before bed has more positive impact on sleep, clearer guidelines needed on melatonin use in children and more. Read the full coverage here: FDA committee says Leqembi shows benefits in early Alzheimer’s Sex before bed has more positive impact on sleep vs. medication in adults with in…
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On this special episode of Rheuminations, I interview comedian and ophthalmologist William Flanary, MD, and Kristin Flanary, also known as the Glaucomfleckens, on hypermobility and physician burnout. Kristen Flanary highlights what it's like to live with hypermobility, and Dr. William Flanary discusses his thoughts on physician burnout and using th…
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In this edition, prior authorization linked delay in prescription fills; disparities in access to specialized cancer centers; ‘new potential treatment option’ for advanced chronic lymphocytic leukemia and more. Read the full coverage here: Prior authorization policies linked to 2-week delay in anticancer-drug prescription fills AYAs with rare leuke…
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In this edition, surgery confers higher 5-year survival rates than radiotherapy; first-line combination extends PFS in lung cancer subgroup; pembrolizumab improves outcomes in early-stage resectable lung cancer, and more. Read the full coverage here: Surgery confers higher 5-year survival rates than radiotherapy in early-stage lung cancer First-lin…
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In this edition, cross-border partnership takes on survival gap for children with leukemia; ‘paradigm shift’ in transfusion-dependent myelodysplastic syndrome; FDA approves Ayvakit for mastocytosis and more. Read the full coverage here: Cross-border partnership takes on ‘huge survival gap’ among children with leukemia Luspatercept ‘a paradigm shift…
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In this edition, FDA approves supplemental new drug application for Rexulti, early amyloid PET provides high diagnostic confidence, Leqembi reduced biomarkers of Alzheimer’s and more. Read the full coverage here: FDA approves supplemental new drug application for Rexulti to treat Alzheimer's agitation Early amyloid PET provides high diagnostic conf…
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In this edition, we bring you a deep dive on a collaboration that aims to accelerate better treatments for pediatric cancers. Read the full coverage here: Collaboration aims to ‘truly accelerate better treatments’ for pediatric cancers References: Dharia NV, et al. Nat Med. 2021;doi:10.1038/s41588-021-00819-w.…
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In this edition, tumor mutational burden linked to immunotherapy response; toripalimab regimen extends EFS in stage III NSCLC; phase 3 study designed for increasing trial diversity, and more. Read the full coverage here: Tumor mutational burden may be linked to immunotherapy response in advanced cancers Perioperative toripalimab regimen extends EFS…
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In this edition, immunotherapy improves survival rates of infants with leukemia; extreme poverty linked to higher risk for relapse among children with ALL; FDA approves allogeneic cell therapy and more. Read the full coverage here: Addition of immunotherapy to chemotherapy improves survival rates of infants with leukemia Extreme poverty linked to n…
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In this edition, trichloroethylene may be ‘invisible’ cause of PD, ravulizumab reduces clinical deterioration in generalized myasthenia gravis and more. Read the full coverage here: Trichloroethylene may be ‘invisible and highly preventable’ cause of Parkinson’s disease DEA petitioned to de-schedule dual orexin receptor antagonist insomnia medicati…
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In this edition, elevated cardiotoxicity risk for Black patients after chemotherapy; CV risk factor disparities in childhood cancer survivors; neural network helps identify potential targets for cancer drugs and more. Read the full coverage here: Black patients may be at elevated cardiotoxicity, HF risk after chemotherapy CV risk factor disparities…
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In this edition, DNA sequencing could identify patients with high-risk AML; review of major advances and challenges in chronic lymphocytic leukemia; FDA advisory panel backs polatuzumab vedotin and more. Read the full coverage here: DNA sequencing could identify patients with AML at high risk for relapse after HSCT Review highlights major advances,…
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