American Journal Of Physiology-Gastrointestinal And Liver Physiology podcast

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The Agile Brand with Greg Kihlström®

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#669: It's already time to start planning for the holiday shopping season with Carey Cockrum, Cella by Randstad Digital 28:52

for 7 dager siden28:52

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Retailers are facing a rapidly evolving landscape where consumer expectations, AI advancements, and social media platforms like TikTok are redefining engagement. It feels like the holiday shopping season just ended, but when do retailers start planning for the next one, and some retailers already behind the curve for this season? Joining us today is Carey Cockrum, Director of Consulting at Cella by Randstad Digital, where she helps major brands and marketing teams optimize their strategies with data-driven insights, AI-powered content creation, and cutting-edge retail marketing trends. With the holidays just around the corner, she’s here to share what’s next for retail marketing, campaign optimization, and how brands can stay ahead in a hyper-competitive space. ABOUT CAREY COCKRUM Carey has been a part of the Creative Agency space for nearly 30 years. She has served as Designer, Creative Director, Creative Operations Lead and Agency Lead in both internal and external agencies (big and small). Carey has worked directly with C-suite stakeholders to understand organizational strategies that inform effective creative solutions. She is a bit of a data nerd and loves demonstrating results. Brands she’s supported include Fruit of the Loom, Wendy’s and Humana. In her free time, she enjoys going back to her creative roots through painting and drawing. She also spends her time improving upon the house she lives in today in Southern, MI - inside and out. RESOURCES Catch the future of e-commerce at eTail Boston, August 11-14, 2025. Register now: https://bit.ly/etailboston and use code PARTNER20 for 20% off for retailers and brands Don't Miss MAICON 2025, October 14-16 in Cleveland - the event bringing together the brights minds and leading voices in AI. Use Code AGILE150 for $150 off registration. Go here to register: https://bit.ly/agile150 Connect with Greg on LinkedIn: https://www.linkedin.com/in/gregkihlstrom Don't miss a thing: get the latest episodes, sign up for our newsletter and more: https://www.theagilebrand.show Check out The Agile Brand Guide website with articles, insights, and Martechipedia, the wiki for marketing technology: https://www.agilebrandguide.com The Agile Brand podcast is brought to you by TEKsystems. Learn more here: https://www.teksystems.com/versionnextnow The Agile Brand is produced by Missing Link—a Latina-owned strategy-driven, creatively fueled production co-op. From ideation to creation, they craft human connections through intelligent, engaging and informative content. https://www.missinglink.company…

American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

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Podcasts of the American Journal of Physiology-Gastrointestinal and Liver Physiology

44 episoder

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American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

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Podcasts of the American Journal of Physiology-Gastrointestinal and Liver Physiology

44 episoder

#Science #ajpgi

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American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

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Unraveling Fabry Disease: Lyso-Gb3’s Role in Gut Physiology 12:22

for 20 dager siden12:22

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In this episode, coauthors Cecilia Delprete, Friederike Uhlig, Marco Caprini, and Niall P. Hyland dive into their latest research titled "Characterization of Fabry disease-associated lyso-Gb3 on mouse colonic ion transport and motility." Fabry disease (FD) is a rare genetic disorder with wide-ranging effects across the body, including the gastrointestinal (GI) system—often one of the first to show symptoms. The team explores how the lipid molecule lyso-Gb3, known to accumulate in FD, affects colonic function using ex vivo techniques like Ussing chambers and organ baths. The conversation covers key findings: lyso-Gb3 significantly alters ion transport in the colon but doesn't affect motility or nerve responses, suggesting a complex mechanism behind GI symptoms in FD patients. Could this bring us closer to understanding—and eventually treating—the GI discomfort that burdens so many with Fabry disease? Tune in today! Characterization of Fabry disease-associated lyso-Gb3 on mouse colonic ion transport and motility Cecilia Delprete, Friederike Uhlig, Marco Caprini, and Niall P. Hyland American Journal of Physiology-Gastrointestinal and Liver Physiology 2024 327:6, G810-G817…

American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

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Got Guts: A Chance to Put Liver Biopsy Back to Its Former Glory? 6:37

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In this episode, coauthors Camilla Venturin and Luca Fabris delve into their editorial titled "Machine Learning Application to Histology for the Study of Cholangiopathies (BiliQML): A Chance to Put Liver Biopsy Back to Its Former Glory?" The episode explores groundbreaking research by Dominick Hellen and colleagues on the limitations of current histological techniques in studying cholangiocytes and the biliary tree. Historically, the study of these cells has been constrained by outdated and error-prone methodologies, like two-dimensional cell counting or complex three-dimensional imaging that fails to provide reliable quantification. Enter BiliQML , a novel machine learning model that promises to revolutionize this field. This episode breaks down how BiliQML quantifies biliary forms using anti-Keratin 19 antibody-stained whole slide images, providing a far more accurate and scalable approach. With an impressive F-score of 0.87, the model's application across a variety of cholangiopathy models, including genetic, surgical, toxicological, and therapeutic, showcases its sensitivity and robustness. The episode reveals how this cutting-edge technology opens new doors for both clinical and basic-science researchers in the field of cholangiopathies. Tune in to discover how machine learning is bringing liver biopsy back to the forefront of research. Machine learning application to histology for the study of cholangiopathies (BiliQML): A chance to put liver biopsy back to its former glory? Camilla Venturin and Luca Fabris American Journal of Physiology-Gastrointestinal and Liver Physiology 2024 327:6, G733-G736…

American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

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"Got Guts" The Micro Version: Pacing Inhibits Slow Wave Dysrhythmias in the Intestine 7:25

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In this podcast coauthors Nipuni D. Nagahawatte and Leo K. Cheng discuss their research titled "High-energy pacing inhibits slow-wave dysrhythmias in the small intestine." Glucagon was infused in pigs to induce hyperglycemia and the resulting slow-wave response in the intact jejunum was defined in high resolution for the first time. Subsequently, with pacing, the glucagon-induced dysrhythmias were suppressed and spatially entrained for the first time with a success rate of 85%. The ability to suppress slow-wave dysrhythmias through pacing is promising in treating motility disorders that are associated with intestinal dysrhythmias. High-energy pacing inhibits slow-wave dysrhythmias in the small intestine Nipuni D. Nagahawatte, Recep Avci, Niranchan Paskaranandavadivel, and Leo K. Cheng American Journal of Physiology-Gastrointestinal and Liver Physiology 2024 326:6, G676-G686…

American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

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"Got Guts" Special Episode: The GI and Liver Section at the 2025 American Physiology Summit 20:09

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In this episode, AJP GI and Liver Physiology's Editor-in-Chief Mark Frey and Nicholas Zachos representative of the Gastrointestinal and Liver Physiology Section provide an exclusive preview of the GI programming at the upcoming APS Summit. They walk listeners through the exciting lineup of sessions, symposia, and featured topics designed to ignite new insights and collaborations within the GI community. From cutting-edge discussions on obesity, metabolic disease, and diet's role in health, to the highly anticipated Game Changer sessions, there's something for everyone to explore. In addition, they highlight some can't-miss events like the John Forte Distinguished Abstract Session, the Trainee Symposium, and the prestigious Davenport Lecture. For those traveling to Baltimore, they also share some insider tips on the best local attractions and places to eat. Whether you're a seasoned professional or a new trainee, this episode gives you everything you need to know to make the most of the APS Summit experience. Tune in for a lively conversation filled with insights, practical advice, and a touch of local flavor!…

American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

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"Got Guts" The Micro Version: Electromechanical Coupling of the In-Vivo Pylorus 13:02

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Join coauthors Sam Simmonds, Ashton Matthee, and Timothy R. Angeli-Gordon as they delve into their recently published research, " Electromechanical Coupling and Anatomy of the In Vivo Gastroduodenal Junction ." In this episode, they explore cutting-edge techniques like electrical mapping, impedance planimetry, and histological analysis to investigate the complex dynamics of the gastroduodenal junction. Discover how contractions in the terminal antrum and pyloric sphincter correlate with gastric slow waves, while the duodenum experiences bursts of spike activity that trigger oscillating contractions. The team discusses their intriguing hypothesis regarding the relative scarcity of myenteric interstitial cells of Cajal in the pylorus, which may hinder coupling between antral and duodenal slow waves. Electromechanical coupling and anatomy of the in vivo gastroduodenal junction Sam Simmonds, Ashton Matthee, Jarrah M. Dowrick, Andrew J. Taberner, Peng Du, and Timothy R. Angeli-Gordon American Journal of Physiology-Gastrointestinal and Liver Physiology 2024 327:1, G93-G104…

American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

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"Got Guts" The Micro Version: Effect of amniotic fluid on the esophageal epithelium 7:50

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Join coauthors Mark Rochman and Marc E. Rothenberg as they explore their recently published paper, " Amniotic Fluid Modifies Esophageal Epithelium Differentiation and Inflammatory Responses ." In this engaging episode, they discuss how the interaction between amniotic fluid and the esophageal epithelium during pregnancy impacts epithelial differentiation and influences the tissue's response to inflammatory stimuli, particularly interleukin 13 (IL-13). Discover the potential implications of these findings, including how they may predispose individuals to inflammatory conditions like eosinophilic esophagitis (EoE) later in life. This episode is a must-listen for anyone interested in developmental biology, immunology, and the long-term effects of prenatal exposures on health. Amniotic fluid modifies esophageal epithelium differentiation and inflammatory responses Mark Rochman, Andrea M. Klinger, Julie M. Caldwell, Yoel Sadovsky, and Marc E. Rothenberg American Journal of Physiology-Gastrointestinal and Liver Physiology 2024 327:5, G629-G639…

American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

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"Got Guts" The Micro Version: The Effects of Simulated Gastroesophageal Reflux on Infant Pig Oropharyngeal Feeding Physiology 7:20

for 29 weeks siden7:20

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Join coauthor Chloe Edmonds in this insightful episode as she delves into her recently published paper, " The Effects of Simulated Gastroesophageal Reflux on Infant Pig Oropharyngeal Feeding Physiology ." Chloe explores how simulating gastroesophageal reflux in an infant pig model reveals significant alterations in pharyngeal swallowing dynamics. Discover how the integration of esophageal afferents impacts motor outputs to the pharynx, leading to decreased swallow frequency and increased bolus sizes. This research not only sheds light on the mechanisms behind esophageal pathologies and oropharyngeal dysphagia but also highlights the potential for developing intervention strategies grounded in neurophysiology. Tune in for a deep dive into the implications of this work for both animal models and clinical practice! Article Citation: The effects of simulated gastroesophageal reflux on infant pig oropharyngeal feeding physiology Chloe E. Edmonds, Kaitlyn N. Robbins, Elizabeth G. Dvorak, Stephen P. Howe, Sarah A. Sheldon, Christopher J. Mayerl, Brianna A. Owairu, Brady M. Young, and Rebecca Z. German American Journal of Physiology-Gastrointestinal and Liver Physiology 2024 327:1, G105-G116…

American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

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"Got Guts" The Micro Version: Autoimmune liver disease and hormonal responses 5:56

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In this episode, coauthors Anne-Sofie H. Jensen and Nicolai J. Wewer Albrechtsen discuss the recently published research titled "Patients with autoimmune liver disease have glucose disturbances that mechanistically differ from steatotic liver disease." The authors reveal that patients with autoimmune liver disease, even in the absence of overt diabetes, experience early glucose disturbances. Jensen and Albrechtsen highlight key pathophysiological traits specific to these patients, including altered incretin responses. This distinction is crucial because it suggests that the mechanisms underlying glucose metabolism issues in autoimmune liver disease differ significantly from those seen in steatotic liver disease. The authors findings could have important implications for diagnosing and managing glucose dysregulation in patients with autoimmune liver conditions. Article Citation Patients with autoimmune liver disease have glucose disturbances that mechanistically differ from steatotic liver disease Anne-Sofie H. Jensen, Henriette Ytting, Mikkel P. Werge, Elias B. Rashu, Liv E. Hetland, Mira Thing, Puria Nabilou, Johan Burisch, Kirstine N. Bojsen-Møller, Anders E. Junker, Lise Hobolth, Christian Mortensen, Flemming Tofteng, Flemming Bendtsen, Søren Møller, Mogens Vyberg, Reza R. Serizawa, Lise L. Gluud, and Nicolai J. Wewer Albrechtsen American Journal of Physiology-Gastrointestinal and Liver Physiology 2024 326:6, G736-G746…

American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

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"Got Guts" The Micro Version: Inhibitory neurotransmission in the internal anal sphincter 8:43

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Coauthor Caroline A. Cobine dives into the fascinating world of internal anal sphincter biology in the latest episode of "Gut Guts." The research uncovers direct and indirect neural pathways that modulate intracellular calcium activity in interstitial cells of Cajal, shedding light on their role in smooth muscle cell function. Article Citation: Modulation of intracellular calcium activity in interstitial cells of Cajal by inhibitory neural pathways within the internal anal sphincter Karen I. Hannigan, Emer P. Ni Bhraonain, Thomas W. Gould, Kathleen D. Keef, and Caroline A. Cobine American Journal of Physiology-Gastrointestinal and Liver Physiology 2024 327:3, G382-G404…

American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

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"Got Guts" The Micro Version: Mechanical Stress-induced Connective Tissue Growth Factor and Intestinal Fibrosis 8:25

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In this episode of "Gut Guts" coauthor Xuan-Zheng Shi discusses new research on intestinal fibrosis in Crohn’s-like colitis. The study found that mechanical stress causes a protein called CTGF to increase, leading to fibrosis. In a rat model, easing the mechanical stress reduced connective tissue growth factor (CTGF) and lessened fibrosis. This suggests that mechanical stress may be important in causing fibrosis in Crohn’s disease. Article Citation: Mechanical stress-induced connective tissue growth factor plays a critical role in intestinal fibrosis in Crohn’s-like colitis You-Min Lin, Ke Zhang, Ramasatyaveni Geesala, Kenneth E. Lipson, Suimin Qiu, Don W. Powell, Steven Cohn, and Xuan-Zheng Shi American Journal of Physiology-Gastrointestinal and Liver Physiology 2024 327:2, G295-G305…

American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

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"Got Guts" The Micro Version: Characterization of Rat Gastric Slow Wave Activity 8:29

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Tune in to our latest podcast episode where Peng Du, Omkar N. Athavale, and Madeleine R. Di Natale dive into the fascinating world of gastric slow-wave conduction. They discuss their recent article titled "Mapping the rat gastric slow-wave conduction pathway: bridging in vitro and in vivo methods, revealing a loosely coupled region in the distal stomach" revealing regional variations in the organization of rat gastric slow waves. Don't miss this intriguing discussion bridging in vitro and in vivo methods! Mapping of rat gastric slow waves showed regional variations in their organization. In some subjects, separate wavefronts propagated near the lesser and greater curvatures with a loosely coupled region near the midline, between the wavefronts, having a varying slow-wave origin. Furthermore, simultaneous intracellular and extracellular recordings were concordant and independent of movement artifacts, indicating that extracellular recordings can be interpreted in terms of their intracellular counterparts when intracellular recording is not possible. Article Citation: Mapping the rat gastric slow-wave conduction pathway: bridging in vitro and in vivo methods, revealing a loosely coupled region in the distal stomach Omkar N. Athavale, Madeleine R. Di Natale, Recep Avci, Alys R. Clark, John B. Furness, Leo K. Cheng, and Peng Du American Journal of Physiology-Gastrointestinal and Liver Physiology 2024 327:2, G254-G266…

American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

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"Got Guts" The Micro Version: Implicating the Cholecystokinin B Receptor in Liver Stem Cell Oncogenesis 4:39

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In this episode of "Got Guts" The Micro Version, Jill P. Smith highlights the recently published research titled "Implicating the cholecystokinin B receptor in liver stem cell oncogenesis." This investigation identified a novel pathway involving the activation of hepatic stem cells and liver oncogenesis. Receptor blockade or genetic disruption of the cholecystokinin-B receptor (CCK-BR) signaling pathway decreased the activation and proliferation of hepatic stem cells after liver injury without eliminating the regenerative capacity of healthy hepatocytes. Article Citation: Implicating the cholecystokinin B receptor in liver stem cell oncogenesis Martha D. Gay, Jack C. Drda, Wenqiang Chen, Yimeng Huang, Amal A. Yassin, Tetyana Duka, Hongbin Fang, Narayan Shivapurkar, and Jill P. Smith American Journal of Physiology-Gastrointestinal and Liver Physiology 2024 326:3, G291-G309…

American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

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"Got Guts" The Micro Version: Corticotropin-Releasing Hormone Effects on Gastric Function 6:26

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In this podcast, I-Hsuan Huang highlights the recently published paper titled " Effects of corticotropin-releasing hormone on gastric electrical activity and sensorimotor function in healthy volunteers: a double-blinded crossover study. " The aim of this research was to investigate the effects of peripheral corticotropin-releasing hormone infusion on meal-related gastrointestinal symptoms, gastric electrical activity, and gastric sensorimotor function in healthy volunteers (HVs). NEW & NOTEWORTHY In healthy volunteers, peripheral corticotropin-releasing hormone (CRH) infusion accelerates gastric-emptying rate and increases postprandial gastric response, accompanied by a rise in symptoms, but does not alter gastric sensitivity or meal-induced accommodation. These findings underscore a significant link between stress and dyspeptic symptoms, with CRH playing a pivotal role in mediating these effects. Article Citation: Effects of corticotropin-releasing hormone on gastric electrical activity and sensorimotor function in healthy volunteers: a double-blinded crossover study I-Hsuan Huang, Jolien Schol, Stefan Calder, Armen A. Gharibans, Karen Van den Houte, Annelies Verheyden, Bert Broeders, Florencia Carbone, Greg O'Grady, and Jan Tack American Journal of Physiology-Gastrointestinal and Liver Physiology 2024 326:5, G622-G630…

American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

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"Got Guts" The Micro Version: Effects of L. Casei-Fermented Milk on Mice with DSS Colitis 7:07

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Coauthors Mélanie G. Gareau and Maria L. Marco delve into the findings of their latest research titled " Milk and Lacticaseibacillus paracasei BL23 effects on intestinal responses in a murine model of colitis ." This study marked the first exploration into sex-dependent responses to probiotic Lacticaseibacillus paracasei and milk, as well as the potential of the dairy matrix to enhance probiotic protection against colitis. Surprisingly, female mice exhibited greater sensitivity to colonic injury compared to their male counterparts, and neither treatment effectively mitigated inflammation in both sexes. These sex-specific reactions may be attributed to variances in the baseline proportions of Akkermansia in the gut microbiome of female mice, shedding light on the intricate interplay between sex, diet, probiotics, and colitis outcomes. Article Citation: Milk and Lacticaseibacillus paracasei BL23 effects on intestinal responses in a murine model of colitis Glory Bui, Cristina Torres-Fuentes, Matteo M. Pusceddu, Mélanie G. Gareau, and Maria L. Marco American Journal of Physiology-Gastrointestinal and Liver Physiology 2024 326:6, G659-G675…

American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

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"Got Guts" The Micro Version: Characterize Mouse Glutamatergic Myenteric Neurons 6:22

for 51 weeks siden6:22

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In this episode, Jia Liu and Bin Feng highlight the recently published research titled "Morphological, molecular, and functional characterization of mouse glutamatergic myenteric neurons." In this research, the authors reveal that VGLUT2-positive enteric neurons (EN), although constituting a small fraction of total EN, are homogeneously expressed in the myenteric ganglia, with a slight concentration at the intermediate region between the colon and rectum. Through anatomic, molecular, and functional analyses, we demonstrated that VGLUT2-ENs are activated indirectly by noxious circumferential colorectal stretch via nicotinic cholinergic transmission, suggesting their participation in mechanical visceral nociception. Article Citation: Morphological, molecular, and functional characterization of mouse glutamatergic myenteric neurons Jia Liu, Shaopeng Zhang, Sharareh Emadi, Tiantian Guo, Longtu Chen, and Bin Feng American Journal of Physiology-Gastrointestinal and Liver Physiology 2024 326:3, G279-G290…

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