American Journal Of Physiology-Gastrointestinal And Liver Physiology podcast

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Helpless Hydrangea 6:24

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Grumpy helps a reader choose the best hydrangea for their hometown. Plus, Grumpy’s gripe of the week. You can find us online at southernliving.com/askgrumpy Ask Grumpy Credits: Steve Bender aka The Grumpy Gardener - Host Nellah McGough - Co-Host Krissy Tiglias - GM, Southern Living Lottie Leymarie - Executive Producer Michael Onufrak - Audio Engineer/Producer Isaac Nunn - Recording Tech Learn more about your ad choices. Visit podcastchoices.com/adchoices…

American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

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Podcasts of the American Journal of Physiology-Gastrointestinal and Liver Physiology

44 episoder

#Science #ajpgi

American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

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Podcasts of the American Journal of Physiology-Gastrointestinal and Liver Physiology

44 episoder

#Science #ajpgi

Alle episoder

1
Unraveling Fabry Disease: Lyso-Gb3’s Role in Gut Physiology 12:22

for 5 weeks siden12:22

12:22

In this episode, coauthors Cecilia Delprete, Friederike Uhlig, Marco Caprini, and Niall P. Hyland dive into their latest research titled "Characterization of Fabry disease-associated lyso-Gb3 on mouse colonic ion transport and motility." Fabry disease (FD) is a rare genetic disorder with wide-ranging effects across the body, including the gastrointestinal (GI) system—often one of the first to show symptoms. The team explores how the lipid molecule lyso-Gb3, known to accumulate in FD, affects colonic function using ex vivo techniques like Ussing chambers and organ baths. The conversation covers key findings: lyso-Gb3 significantly alters ion transport in the colon but doesn't affect motility or nerve responses, suggesting a complex mechanism behind GI symptoms in FD patients. Could this bring us closer to understanding—and eventually treating—the GI discomfort that burdens so many with Fabry disease? Tune in today! Characterization of Fabry disease-associated lyso-Gb3 on mouse colonic ion transport and motility Cecilia Delprete, Friederike Uhlig, Marco Caprini, and Niall P. Hyland American Journal of Physiology-Gastrointestinal and Liver Physiology 2024 327:6, G810-G817…

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Got Guts: A Chance to Put Liver Biopsy Back to Its Former Glory? 6:37

for 10 weeks siden6:37

6:37

In this episode, coauthors Camilla Venturin and Luca Fabris delve into their editorial titled "Machine Learning Application to Histology for the Study of Cholangiopathies (BiliQML): A Chance to Put Liver Biopsy Back to Its Former Glory?" The episode explores groundbreaking research by Dominick Hellen and colleagues on the limitations of current histological techniques in studying cholangiocytes and the biliary tree. Historically, the study of these cells has been constrained by outdated and error-prone methodologies, like two-dimensional cell counting or complex three-dimensional imaging that fails to provide reliable quantification. Enter BiliQML , a novel machine learning model that promises to revolutionize this field. This episode breaks down how BiliQML quantifies biliary forms using anti-Keratin 19 antibody-stained whole slide images, providing a far more accurate and scalable approach. With an impressive F-score of 0.87, the model's application across a variety of cholangiopathy models, including genetic, surgical, toxicological, and therapeutic, showcases its sensitivity and robustness. The episode reveals how this cutting-edge technology opens new doors for both clinical and basic-science researchers in the field of cholangiopathies. Tune in to discover how machine learning is bringing liver biopsy back to the forefront of research. Machine learning application to histology for the study of cholangiopathies (BiliQML): A chance to put liver biopsy back to its former glory? Camilla Venturin and Luca Fabris American Journal of Physiology-Gastrointestinal and Liver Physiology 2024 327:6, G733-G736…

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"Got Guts" The Micro Version: Pacing Inhibits Slow Wave Dysrhythmias in the Intestine 7:25

for 13 weeks siden7:25

7:25

In this podcast coauthors Nipuni D. Nagahawatte and Leo K. Cheng discuss their research titled "High-energy pacing inhibits slow-wave dysrhythmias in the small intestine." Glucagon was infused in pigs to induce hyperglycemia and the resulting slow-wave response in the intact jejunum was defined in high resolution for the first time. Subsequently, with pacing, the glucagon-induced dysrhythmias were suppressed and spatially entrained for the first time with a success rate of 85%. The ability to suppress slow-wave dysrhythmias through pacing is promising in treating motility disorders that are associated with intestinal dysrhythmias. High-energy pacing inhibits slow-wave dysrhythmias in the small intestine Nipuni D. Nagahawatte, Recep Avci, Niranchan Paskaranandavadivel, and Leo K. Cheng American Journal of Physiology-Gastrointestinal and Liver Physiology 2024 326:6, G676-G686…

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"Got Guts" Special Episode: The GI and Liver Section at the 2025 American Physiology Summit 20:09

for 17 weeks siden20:09

20:09

In this episode, AJP GI and Liver Physiology's Editor-in-Chief Mark Frey and Nicholas Zachos representative of the Gastrointestinal and Liver Physiology Section provide an exclusive preview of the GI programming at the upcoming APS Summit. They walk listeners through the exciting lineup of sessions, symposia, and featured topics designed to ignite new insights and collaborations within the GI community. From cutting-edge discussions on obesity, metabolic disease, and diet's role in health, to the highly anticipated Game Changer sessions, there's something for everyone to explore. In addition, they highlight some can't-miss events like the John Forte Distinguished Abstract Session, the Trainee Symposium, and the prestigious Davenport Lecture. For those traveling to Baltimore, they also share some insider tips on the best local attractions and places to eat. Whether you're a seasoned professional or a new trainee, this episode gives you everything you need to know to make the most of the APS Summit experience. Tune in for a lively conversation filled with insights, practical advice, and a touch of local flavor!…

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"Got Guts" The Micro Version: Electromechanical Coupling of the In-Vivo Pylorus 13:02

for 29 weeks siden13:02

13:02

Join coauthors Sam Simmonds, Ashton Matthee, and Timothy R. Angeli-Gordon as they delve into their recently published research, " Electromechanical Coupling and Anatomy of the In Vivo Gastroduodenal Junction ." In this episode, they explore cutting-edge techniques like electrical mapping, impedance planimetry, and histological analysis to investigate the complex dynamics of the gastroduodenal junction. Discover how contractions in the terminal antrum and pyloric sphincter correlate with gastric slow waves, while the duodenum experiences bursts of spike activity that trigger oscillating contractions. The team discusses their intriguing hypothesis regarding the relative scarcity of myenteric interstitial cells of Cajal in the pylorus, which may hinder coupling between antral and duodenal slow waves. Electromechanical coupling and anatomy of the in vivo gastroduodenal junction Sam Simmonds, Ashton Matthee, Jarrah M. Dowrick, Andrew J. Taberner, Peng Du, and Timothy R. Angeli-Gordon American Journal of Physiology-Gastrointestinal and Liver Physiology 2024 327:1, G93-G104…

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"Got Guts" The Micro Version: Effect of amniotic fluid on the esophageal epithelium 7:50

for 31 weeks siden7:50

7:50

Join coauthors Mark Rochman and Marc E. Rothenberg as they explore their recently published paper, " Amniotic Fluid Modifies Esophageal Epithelium Differentiation and Inflammatory Responses ." In this engaging episode, they discuss how the interaction between amniotic fluid and the esophageal epithelium during pregnancy impacts epithelial differentiation and influences the tissue's response to inflammatory stimuli, particularly interleukin 13 (IL-13). Discover the potential implications of these findings, including how they may predispose individuals to inflammatory conditions like eosinophilic esophagitis (EoE) later in life. This episode is a must-listen for anyone interested in developmental biology, immunology, and the long-term effects of prenatal exposures on health. Amniotic fluid modifies esophageal epithelium differentiation and inflammatory responses Mark Rochman, Andrea M. Klinger, Julie M. Caldwell, Yoel Sadovsky, and Marc E. Rothenberg American Journal of Physiology-Gastrointestinal and Liver Physiology 2024 327:5, G629-G639…

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"Got Guts" The Micro Version: The Effects of Simulated Gastroesophageal Reflux on Infant Pig Oropharyngeal Feeding Physiology 7:20

for 31 weeks siden7:20

7:20

Join coauthor Chloe Edmonds in this insightful episode as she delves into her recently published paper, " The Effects of Simulated Gastroesophageal Reflux on Infant Pig Oropharyngeal Feeding Physiology ." Chloe explores how simulating gastroesophageal reflux in an infant pig model reveals significant alterations in pharyngeal swallowing dynamics. Discover how the integration of esophageal afferents impacts motor outputs to the pharynx, leading to decreased swallow frequency and increased bolus sizes. This research not only sheds light on the mechanisms behind esophageal pathologies and oropharyngeal dysphagia but also highlights the potential for developing intervention strategies grounded in neurophysiology. Tune in for a deep dive into the implications of this work for both animal models and clinical practice! Article Citation: The effects of simulated gastroesophageal reflux on infant pig oropharyngeal feeding physiology Chloe E. Edmonds, Kaitlyn N. Robbins, Elizabeth G. Dvorak, Stephen P. Howe, Sarah A. Sheldon, Christopher J. Mayerl, Brianna A. Owairu, Brady M. Young, and Rebecca Z. German American Journal of Physiology-Gastrointestinal and Liver Physiology 2024 327:1, G105-G116…

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"Got Guts" The Micro Version: Autoimmune liver disease and hormonal responses 5:56

for 34 weeks siden5:56

5:56

In this episode, coauthors Anne-Sofie H. Jensen and Nicolai J. Wewer Albrechtsen discuss the recently published research titled "Patients with autoimmune liver disease have glucose disturbances that mechanistically differ from steatotic liver disease." The authors reveal that patients with autoimmune liver disease, even in the absence of overt diabetes, experience early glucose disturbances. Jensen and Albrechtsen highlight key pathophysiological traits specific to these patients, including altered incretin responses. This distinction is crucial because it suggests that the mechanisms underlying glucose metabolism issues in autoimmune liver disease differ significantly from those seen in steatotic liver disease. The authors findings could have important implications for diagnosing and managing glucose dysregulation in patients with autoimmune liver conditions. Article Citation Patients with autoimmune liver disease have glucose disturbances that mechanistically differ from steatotic liver disease Anne-Sofie H. Jensen, Henriette Ytting, Mikkel P. Werge, Elias B. Rashu, Liv E. Hetland, Mira Thing, Puria Nabilou, Johan Burisch, Kirstine N. Bojsen-Møller, Anders E. Junker, Lise Hobolth, Christian Mortensen, Flemming Tofteng, Flemming Bendtsen, Søren Møller, Mogens Vyberg, Reza R. Serizawa, Lise L. Gluud, and Nicolai J. Wewer Albrechtsen American Journal of Physiology-Gastrointestinal and Liver Physiology 2024 326:6, G736-G746…

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"Got Guts" The Micro Version: Inhibitory neurotransmission in the internal anal sphincter 8:43

for 37 weeks siden8:43

8:43

Coauthor Caroline A. Cobine dives into the fascinating world of internal anal sphincter biology in the latest episode of "Gut Guts." The research uncovers direct and indirect neural pathways that modulate intracellular calcium activity in interstitial cells of Cajal, shedding light on their role in smooth muscle cell function. Article Citation: Modulation of intracellular calcium activity in interstitial cells of Cajal by inhibitory neural pathways within the internal anal sphincter Karen I. Hannigan, Emer P. Ni Bhraonain, Thomas W. Gould, Kathleen D. Keef, and Caroline A. Cobine American Journal of Physiology-Gastrointestinal and Liver Physiology 2024 327:3, G382-G404…

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"Got Guts" The Micro Version: Mechanical Stress-induced Connective Tissue Growth Factor and Intestinal Fibrosis 8:25

for 39 weeks siden8:25

8:25

In this episode of "Gut Guts" coauthor Xuan-Zheng Shi discusses new research on intestinal fibrosis in Crohn’s-like colitis. The study found that mechanical stress causes a protein called CTGF to increase, leading to fibrosis. In a rat model, easing the mechanical stress reduced connective tissue growth factor (CTGF) and lessened fibrosis. This suggests that mechanical stress may be important in causing fibrosis in Crohn’s disease. Article Citation: Mechanical stress-induced connective tissue growth factor plays a critical role in intestinal fibrosis in Crohn’s-like colitis You-Min Lin, Ke Zhang, Ramasatyaveni Geesala, Kenneth E. Lipson, Suimin Qiu, Don W. Powell, Steven Cohn, and Xuan-Zheng Shi American Journal of Physiology-Gastrointestinal and Liver Physiology 2024 327:2, G295-G305…

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"Got Guts" The Micro Version: Characterization of Rat Gastric Slow Wave Activity 8:29

for 40 weeks siden8:29

8:29

Tune in to our latest podcast episode where Peng Du, Omkar N. Athavale, and Madeleine R. Di Natale dive into the fascinating world of gastric slow-wave conduction. They discuss their recent article titled "Mapping the rat gastric slow-wave conduction pathway: bridging in vitro and in vivo methods, revealing a loosely coupled region in the distal stomach" revealing regional variations in the organization of rat gastric slow waves. Don't miss this intriguing discussion bridging in vitro and in vivo methods! Mapping of rat gastric slow waves showed regional variations in their organization. In some subjects, separate wavefronts propagated near the lesser and greater curvatures with a loosely coupled region near the midline, between the wavefronts, having a varying slow-wave origin. Furthermore, simultaneous intracellular and extracellular recordings were concordant and independent of movement artifacts, indicating that extracellular recordings can be interpreted in terms of their intracellular counterparts when intracellular recording is not possible. Article Citation: Mapping the rat gastric slow-wave conduction pathway: bridging in vitro and in vivo methods, revealing a loosely coupled region in the distal stomach Omkar N. Athavale, Madeleine R. Di Natale, Recep Avci, Alys R. Clark, John B. Furness, Leo K. Cheng, and Peng Du American Journal of Physiology-Gastrointestinal and Liver Physiology 2024 327:2, G254-G266…

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"Got Guts" The Micro Version: Implicating the Cholecystokinin B Receptor in Liver Stem Cell Oncogenesis 4:39

for 48 weeks siden4:39

4:39

In this episode of "Got Guts" The Micro Version, Jill P. Smith highlights the recently published research titled "Implicating the cholecystokinin B receptor in liver stem cell oncogenesis." This investigation identified a novel pathway involving the activation of hepatic stem cells and liver oncogenesis. Receptor blockade or genetic disruption of the cholecystokinin-B receptor (CCK-BR) signaling pathway decreased the activation and proliferation of hepatic stem cells after liver injury without eliminating the regenerative capacity of healthy hepatocytes. Article Citation: Implicating the cholecystokinin B receptor in liver stem cell oncogenesis Martha D. Gay, Jack C. Drda, Wenqiang Chen, Yimeng Huang, Amal A. Yassin, Tetyana Duka, Hongbin Fang, Narayan Shivapurkar, and Jill P. Smith American Journal of Physiology-Gastrointestinal and Liver Physiology 2024 326:3, G291-G309…

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"Got Guts" The Micro Version: Corticotropin-Releasing Hormone Effects on Gastric Function 6:26

for 50 weeks siden6:26

6:26

In this podcast, I-Hsuan Huang highlights the recently published paper titled " Effects of corticotropin-releasing hormone on gastric electrical activity and sensorimotor function in healthy volunteers: a double-blinded crossover study. " The aim of this research was to investigate the effects of peripheral corticotropin-releasing hormone infusion on meal-related gastrointestinal symptoms, gastric electrical activity, and gastric sensorimotor function in healthy volunteers (HVs). NEW & NOTEWORTHY In healthy volunteers, peripheral corticotropin-releasing hormone (CRH) infusion accelerates gastric-emptying rate and increases postprandial gastric response, accompanied by a rise in symptoms, but does not alter gastric sensitivity or meal-induced accommodation. These findings underscore a significant link between stress and dyspeptic symptoms, with CRH playing a pivotal role in mediating these effects. Article Citation: Effects of corticotropin-releasing hormone on gastric electrical activity and sensorimotor function in healthy volunteers: a double-blinded crossover study I-Hsuan Huang, Jolien Schol, Stefan Calder, Armen A. Gharibans, Karen Van den Houte, Annelies Verheyden, Bert Broeders, Florencia Carbone, Greg O'Grady, and Jan Tack American Journal of Physiology-Gastrointestinal and Liver Physiology 2024 326:5, G622-G630…

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"Got Guts" The Micro Version: Effects of L. Casei-Fermented Milk on Mice with DSS Colitis 7:07

for 52 weeks siden7:07

7:07

Coauthors Mélanie G. Gareau and Maria L. Marco delve into the findings of their latest research titled " Milk and Lacticaseibacillus paracasei BL23 effects on intestinal responses in a murine model of colitis ." This study marked the first exploration into sex-dependent responses to probiotic Lacticaseibacillus paracasei and milk, as well as the potential of the dairy matrix to enhance probiotic protection against colitis. Surprisingly, female mice exhibited greater sensitivity to colonic injury compared to their male counterparts, and neither treatment effectively mitigated inflammation in both sexes. These sex-specific reactions may be attributed to variances in the baseline proportions of Akkermansia in the gut microbiome of female mice, shedding light on the intricate interplay between sex, diet, probiotics, and colitis outcomes. Article Citation: Milk and Lacticaseibacillus paracasei BL23 effects on intestinal responses in a murine model of colitis Glory Bui, Cristina Torres-Fuentes, Matteo M. Pusceddu, Mélanie G. Gareau, and Maria L. Marco American Journal of Physiology-Gastrointestinal and Liver Physiology 2024 326:6, G659-G675…

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"Got Guts" The Micro Version: Characterize Mouse Glutamatergic Myenteric Neurons 6:22

for 1 year siden6:22

6:22

In this episode, Jia Liu and Bin Feng highlight the recently published research titled "Morphological, molecular, and functional characterization of mouse glutamatergic myenteric neurons." In this research, the authors reveal that VGLUT2-positive enteric neurons (EN), although constituting a small fraction of total EN, are homogeneously expressed in the myenteric ganglia, with a slight concentration at the intermediate region between the colon and rectum. Through anatomic, molecular, and functional analyses, we demonstrated that VGLUT2-ENs are activated indirectly by noxious circumferential colorectal stretch via nicotinic cholinergic transmission, suggesting their participation in mechanical visceral nociception. Article Citation: Morphological, molecular, and functional characterization of mouse glutamatergic myenteric neurons Jia Liu, Shaopeng Zhang, Sharareh Emadi, Tiantian Guo, Longtu Chen, and Bin Feng American Journal of Physiology-Gastrointestinal and Liver Physiology 2024 326:3, G279-G290…

American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

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”Got Guts” The Micro Version: Gastric Neuromuscular Transmission 5:29

for 1 year siden5:29

5:29

In this episode of the Got Guts podcast series Madeleine R. Di Natale of the University of Melbourne discusses the recently published manuscript titled "Characterization of neuromuscular transmission and projections of muscle motor neurons in the rat stomach." This study provides a detailed mapping of nerve transmission to the circular muscle of the different anatomical regions of rat stomach. It shows that excitatory and inhibitory influences extend around the gastric circumference and that there is a summation of neural influence that allows for finely graded control of muscle tension and length. Nerve-mediated electrical events are qualitatively and quantitatively different between regions, for example, excitatory neurons have direct effects on fundus but not antral muscle. Article Citation: Characterization of neuromuscular transmission and projections of muscle motor neurons in the rat stomach Madeleine R. Di Natale, Billie Hunne, Martin J. Stebbing, Xiaokai Wang, Zhongming Liu, and John B. Furness American Journal of Physiology-Gastrointestinal and Liver Physiology 2024 326:1, G78-G93…

American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

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”Got Guts” The Micro Version: Gene expression and microbiome composition in EsoCaSR-/-mice 7:28

for 1 year siden7:28

7:28

In this episode of the Got Guts Podcast series, Solange M. Abdulnour-Nakhoul of Tulane University, discusses the recently published manuscript titled "Alterations in gene expression and microbiome composition upon calcium sensing receptor deletion in the mouse esophagus." In this research Abdulnour-Nakhoul et al. highlight why calcium sensing receptor plays a significant role in maintaining the barrier function of esophageal epithelium. Article Citation: Alterations in gene expression and microbiome composition upon calcium sensing receptor deletion in the mouse esophagus Solange M. Abdulnour-Nakhoul, Jay K. Kolls, Eric K. Flemington, Nathan A. Ungerleider, Hani N. Nakhoul, Kejing Song, and Nazih L. Nakhoul American Journal of Physiology-Gastrointestinal and Liver Physiology 0 0:0…

American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

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"Got Guts" Special Episode: The GI and Liver Section at the 2024 American Physiology Summit 11:26

for 1 year siden11:26

11:26

Listen as Editor in Chief of AJPGI and Liver Physiology, Mark Frey and the Chair of the Gastrointestinal & Liver Section , Pradeep Dudeja discuss what they are looking forward at the 2024 American Physiology Summit, April 4-7th. Registration Deadline for American Physiology Summit is March 11, 2024. Click here for more info on the American Journal of Physiology Gastrointestinal and Liver Physiology…

American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

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”Got Guts” The Micro Version: Pf Inhibits Inflammation-Induced Epithelial Break-Down 5:16

for 1 year siden5:16

5:16

In this episode Marine Mantel of Nantes Université discusses the recently published research in AJP-GI and Liver Physiology titled "Propionibacterium freudenreichii CIRM-BIA 129 mitigates colitis through S layer protein B-dependent epithelial strengthening ." NEW & NOTEWORTHY Propionibacterium freudenreichii reduces dextran sodium sulfate (DSS)-induced intestinal permeability in vivo . P. freudenreichii does not inhibit inflammation but damages linked to inflammation. P. freudenreichii inhibits intestinal epithelial breakdown through S-layer protein B. The protective effects of P. freudenreichii depend on S-layer protein B. Extracellular vesicles from P. freudenreichii CB 129 mimic the protective effect of the probiotic. Article Citation: Propionibacterium freudenreichii CIRM-BIA 129 mitigates colitis through S layer protein B-dependent epithelial strengthening Marine Mantel, Tony Durand, Anne Bessard, Ségolène Pernet, Julie Beaudeau, Juliana Guimaraes-Laguna, Marie-Bernadette Maillard, Eric Guédon, Michel Neunlist, Yves Le Loir, Gwénaël Jan, and Malvyne Rolli-Derkinderen American Journal of Physiology-Gastrointestinal and Liver Physiology 2024 326:2, G163-G175…

American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

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”Got Guts” The Micro Version: IL-4Rα Signaling in Esophageal Smooth Muscle 6:22

for 1 year siden6:22

6:22

In this episode author, Melissa Nelson of Baylor University Medical Center, discusses the recently published manuscript titled "Th2 Cytokine Signaling through IL-4Rα Increases Eotaxin-3 Secretion and Tension in Human Esophageal Smooth Muscle." New and Noteworthy: Nelson et al. have found that Th2 cytokines increase eotaxin-3 secretion and tension in esophageal smooth muscle (ESM) cells via IL-4Rα signaling. Unlike esophageal epithelial cells, ESM cells do not express H+,K+ATPase, and omeprazole does not inhibit their cytokine-stimulated eotaxin-3 secretion or tension. An IL-4Rα blocking antibody reduces both eotaxin-3 secretion and tension induced by Th2 cytokines in ESM cells, suggesting that an agent such as dupilumab might be preferred for EoE patients with esophageal muscle involvement. Article Citation: Th2 Cytokine Signaling through IL-4Rα Increases Eotaxin-3 Secretion and Tension in Human Esophageal Smooth Muscle Melissa R. Nelson, Xi Zhang, Eitan Podgaetz, Xuan Wang, Qiuyang Zhang, Zui Pan, Stuart Jon Spechler, and Rhonda F. Souza American Journal of Physiology-Gastrointestinal and Liver Physiology 0 0:0…

American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

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”Got Guts” The Micro Version: Order of Events after Keratin 8 Sequential Downregulation 6:26

for 1 year siden6:26

6:26

In this podcast, authors Maria A. Ilomäki and Lauri Polari (both at Åbo Akademi University) discuss their recently published research titled “Defining a timeline of colon pathologies after keratin 8 loss: Rapid crypt elongation and diarrhea are followed by epithelial erosion and cell exfoliation.” New and Noteworthy: Understanding the order in which physiological and molecular events occur helps to recognize the onset of diseases and improve their preclinical models. We utilized Cre-Lox-based inducible keratin 8 deletion in mouse intestinal epithelium to characterize the earliest events after keratin 8 loss leading to colitis. These include diarrhea and crypt elongation, followed by erosion and neutrophil activity. The authors results also support noninvasive methodology for monitoring colon diseases in preclinical models. Article Citation: Defining a timeline of colon pathologies after keratin 8 loss: Rapid crypt elongation and diarrhea are followed by epithelial erosion and cell exfoliation Maria A. Ilomäki, Lauri Polari, Carl-Gustaf A. Stenvall, Mina Tayyab, Kirah Kähärä, Karen M. Ridge, and Diana M. Toivola American Journal of Physiology-Gastrointestinal and Liver Physiology 0 0:0…

American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

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”Got Guts” The Micro Version: Effects of in utero fluoxetine exposure on the GI tract 4:10

for 1 year siden4:10

4:10

In this episode authors Katherine L. Prowse,, and Elyanne M. Ratcliffe of McMaster University, discuss their recently published article titled “Effects of in utero exposure to fluoxetine on the gastrointestinal tract of rat offspring.” NEW & NOTEWORTHY There is increasing recognition of the relevance of in utero and early postnatal exposures in the developmental programming of the gastrointestinal tract. Perinatal exposure to selective serotonin reuptake inhibitors and antidepressant medications is of particular relevance as they are commonly prescribed during pregnancy, and serotonergic pathways play key roles during gastrointestinal development and in postnatal homeostasis. Here, we provide a comprehensive evaluation of clinically relevant outcomes of gastrointestinal motility and susceptibility to colitis in fluoxetine-exposed offspring and highlight changes in colonic serotonergic neurons at the peak of perinatal fluoxetine exposure with sex-dependent changes in serotonin signaling and colonic motility in adulthood. Article Citation: Effects of in utero exposure to fluoxetine on the gastrointestinal tract of rat offspring Katherine L. Prowse, Harriet Law, Sergio Raez-Villanueva, Filip Markovic, Megan Wang, Rajka Borojevic, Sean P. Parsons, Alexander D. Vincent, Alison C. Holloway, and Elyanne M. Ratcliffe American Journal of Physiology-Gastrointestinal and Liver Physiology 2023 325:6, G528-G538…

American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

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”Got Guts” The Micro Version: Colon ion transporter gene expression during cirrhosis 8:29

for 2 years siden8:29

8:29

Diego Alvarez de la Rosa of the University of La Laguna discusses the recently published manuscript titled “Decaying kidney function during cirrhosis correlates with remodeling of distal colon aldosterone target gene expression.” NEW & NOTEWORTHY Liver cirrhosis progression significantly alters ion transporter subunit expression in the rat distal colon, a change that correlated well with declining kidney function and the severity of the disease. Natalia Serrano-Morillas et al. data suggests that the steroid hormone aldosterone participates in this homeostatic response to maintain electrolyte balance. Article Citation: Decaying kidney function during cirrhosis correlates with remodeling of distal colon aldosterone target gene expression Natalia Serrano-Morillas, Carlos González-Alayón, Arianna Vastola-Mascolo, Ana E. Rodríguez-Rodríguez, Guadalberto Hernández, Esteban Porrini, Manuel Hernández-Guerra, and Diego Alvarez de la Rosa American Journal of Physiology-Gastrointestinal and Liver Physiology 2023 325:4, G306-G317…

American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

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”Got Guts” The Micro Version: Maternal influenza infection and offspring gut immunity 7:40

for 2 years siden7:40

7:40

In this podcast lead author Dr. Stella Liong of RMIT University, discusses the recently published manuscript titled “Influenza A virus infection during pregnancy causes immunological changes in gut-associated lymphoid tissues of offspring mice.” NEW & NOTEWORTHY Influenza A virus (IAV) infection during pregnancy is associated with changes in gut-associated lymphoid tissue (GALT) in the offspring in a region-dependent manner. Neutrophils and monocytes/macrophages were elevated in the cecal patch of offspring from infected dams. This increase in innate immune cell infiltration was not observed in the Peyer’s patches. T cells were also elevated in the cecal patch but not in the Peyer’s patches. Article Citation: Influenza A virus infection during pregnancy causes immunological changes in gut-associated lymphoid tissues of offspring mice Stella Liong, Mark A. Miles, Mitra Mohsenipour, Felicia Liong, Elisa L. Hill-Yardin, and Stavros Selemidis American Journal of Physiology-Gastrointestinal and Liver Physiology 2023 325:3, G230-G238…

American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

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”Got Guts” the Micro Version with Kalidas Ramamoorthy 5:09

for 2 years siden5:09

5:09

First author, Dr. Kalidas Ramamoorthy of the University of California, Irvine discusses the recently published paper titled “miR-122-5p is involved in posttranscriptional regulation of the mitochondrial thiamin pyrophosphate transporter (SLC25A19) in pancreatic acinar cells.” NEW & NOTEWORTHY This study shows that the expression and function of mitochondrial TPP transporter (MTPPT) are subject to posttranscriptional regulation by miRNA-122-5p in pancreatic acinar cells. Article Citation: miR-122-5p is involved in posttranscriptional regulation of the mitochondrial thiamin pyrophosphate transporter ( SLC25A19 ) in pancreatic acinar cells Kalidas Ramamoorthy, Subrata Sabui, Kameron I. Manzon, Appakalai N. Balamurugan, and Hamid M. Said American Journal of Physiology-Gastrointestinal and Liver Physiology 2023 325:4, G347-G355…

American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

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”Got Guts” the Micro Version with Steven Hutchens and Somshuvra Mukhopadhyay 6:30

for 2 years siden6:30

6:30

In this podcast Steven Hutchens and Dr. Somshuvra Mukhopadhyay of the University of Texas at Austin discuss the recently published research titled "Hepatic and intestinal manganese excretion are both required to regulate brain manganese during elevated manganese exposure." NEW & NOTEWORTHY This article shows that, in contrast with expectations from prior studies and physiological conditions, excretion of manganese by the intestines and liver is equally important in controlling brain manganese during human-relevant manganese exposure. The results provide foundational insights about the interorgan mechanisms that control brain manganese homeostasis at the organism level and have important implications for the development of therapeutics to treat manganese-induced neurological disease. Article Citation: Hepatic and intestinal manganese excretion are both required to regulate brain manganese during elevated manganese exposure Steven Hutchens, Thomas P. Jursa, Ashvini Melkote, Stephanie M. Grant, Donald R. Smith, and Somshuvra Mukhopadhyay American Journal of Physiology-Gastrointestinal and Liver Physiology 2023 325:3, G251-G264…

American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

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”Got Guts” the Micro Version with Jihane N. Benhammou 8:42

for 2 years siden8:42

8:42

In this episode, Dr. Jihane N. Benhammou of UCLA discusses the recently published article titled "Lipophilic statins inhibit YAP coactivator transcriptional activity in HCC cells through Rho-mediated modulation of actin cytoskeleton." NEW & NOTEWORTHY Statins are widely used for the treatment of cardiovascular diseases. Recently, their use has been associated with a decrease in the incidence of hepatocellular carcinoma (HCC); however, their mechanism(s) has remained elusive. In this study, we delineate the mechanism by which statins affect the Yes-associated protein (YAP), which has emerged as a key oncogenic pathway in HCC. We investigate each step of the mevalonate pathway and demonstrate that statins regulate YAP via Rho GTPases. Article Citation: Lipophilic statins inhibit YAP coactivator transcriptional activity in HCC cells through Rho-mediated modulation of actin cytoskeleton Jihane N. Benhammou, Bo Qiao, Arthur Ko, James Sinnett-Smith, Joseph R. Pisegna, and Enrique Rozengurt American Journal of Physiology-Gastrointestinal and Liver Physiology 2023 325:3, G239-G250…

American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

1
”Got Guts” the Micro Version with Francisco Pascual and Samuel Camilli 5:19

for 2 years siden5:19

5:19

In this podcast coauthors Francisco Pascual, and Samuel Camilli of Morsani College of Medicine, University of South Florida discuss the recently published Perspectives titled "Mind-body connection: metabolite 4-ethylphenyl linked to anxiety behavior and oligodendrocyte modification in autism spectrum disorder." Article Citation: Mind-body connection: metabolite 4-ethylphenyl linked to anxiety behavior and oligodendrocyte modification in autism spectrum disorder Francisco Pascual, Samuel Camilli, Richard F. Lockey, and Narasaiah Kolliputi American Journal of Physiology-Gastrointestinal and Liver Physiology 2023 324:6, G422-G425…

American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

1
”Got Guts” the Micro Version with Theo A.T.G. van Kempen and Gavin M. Boerboom 7:45

for 2 years siden7:45

7:45

In this podcast Prof. Theo A.T.G. van Kempen of North Carolina State University and Dr. Gavin M. Boerboom of Trouw Nutrition discuss their recently published perspectives paper titled "Is the intestinal mucous layer a natural deep eutectic solvent-based digestion matrix?" Article Citation: Is the intestinal mucous layer a natural deep eutectic solvent-based digestion matrix? Theo A.T.G. van Kempen and Gavin M. Boerboom American Journal of Physiology-Gastrointestinal and Liver Physiology 2023 324:6, G438-G441…

American Journal of Physiology-Gastrointestinal and Liver Physiology Podcast

1
”Got Guts” the Micro Version with Jessica A. Breznik 8:55

for 2 years siden8:55

8:55

In this podcast first author Dr. Jessica A. Breznik of McMaster University, discusses the recently published manuscript titled "Diet-induced obesity alters intestinal monocyte-derived and tissue-resident macrophages and increases intestinal permeability in female mice independent of tumor necrosis factor." NEW & NOTEWORTHY We found that diet-induced obesity in female mice has tissue- and time-dependent effects on intestinal paracellular permeability as well as monocyte-derived and tissue-resident macrophage numbers, surface marker phenotype, and intracellular production of the cytokines IL-10 and TNF. These changes were not mediated by TNF. Article Citation: Diet-induced obesity alters intestinal monocyte-derived and tissue-resident macrophages and increases intestinal permeability in female mice independent of tumor necrosis factor Jessica A. Breznik, Jennifer Jury, Elena F. Verdú, Deborah M. Sloboda, and Dawn M. E. Bowdish American Journal of Physiology-Gastrointestinal and Liver Physiology 2023 324:4, G305-G321…

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The Let Them Theory: A Life-Changing Tool That Millions of People Can't Stop Talking About

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The Let Them Theory: A Life-Changing Tool That Millions of People Can't Stop Talking About

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