Population Genetics

MCAT Basics (from MedSchoolCoach)

In this episode, we discuss population genetics and see how genetically related individuals share the same alleles, delving into the mechanisms of gene flow and genetic drift. We'll also unravel the complexities of hybrid vigor, reproductive isolation, and natural selection, and how these processes shape the genetic landscape of populations.

We'll also touch on the fascinating dynamics of X-linked and mitochondrial inheritance, and the role of genomic imprinting in disease risk. Ever wondered how the Hardy-Weinberg equation helps us understand genetic equilibrium in populations? We've got that covered too, breaking down the assumptions and applications of this essential model. Plus, we'll delve into how allele frequencies can shift due to factors like mutations and population bottlenecks.

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Jump into the conversation:

[00:00] Introduction to the MCAT Basics

[01:06] Overview of Population Genetics

[01:55] Definition of Population Genetics

[03:01] Genotype vs. Phenotype

[03:38] Example of BRCA1 Gene

[07:33] Autosomal Dominant and Recessive Inheritance Patterns

[08:40] X-Linked Inheritance Patterns

[09:38] Mitochondrial Inheritance

[10:46] Genomic Imprinting

[12:46] Complex and Multifactorial Inheritance

[13:52] Introduction to Hardy Weinberg Equation

[14:33] Assumptions of Hardy Weinberg Equation

[15:16] Historical Context of Hardy Weinberg Equation

[17:02] Calculation of Allele Frequencies

[19:18] Example Problem Using Hardy Weinberg Equation

[23:17] Limitations of Hardy Weinberg Equation

[24:07] Ways Populations Change Over Time

[24:58] Natural Selection

[27:10] Fecundity and Fertility in Natural Selection

[28:07] Types of Natural Selection

[30:00] Mutation

[32:17] Example of Mutation in HIV Research

[34:29] Genetic Drift

[38:11] Gene Flow and Gene Leakage

[40:12] Hybrid Vigor and Reproductive Isolation

[42:16] Prepare for MCAT success with MedSchoolCoach.