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EP 116: Genetics and Medicine: Clonal hematopoiesis, genomics in healthcare, and a new discovery in APOL1 kidney disease with Dr. Alex Bick
MP3•Episoder hjem
Manage episode 393540661 series 2631947
Innhold levert av Sano Genetics. Alt podcastinnhold, inkludert episoder, grafikk og podcastbeskrivelser, lastes opp og leveres direkte av Sano Genetics eller deres podcastplattformpartner. Hvis du tror at noen bruker det opphavsrettsbeskyttede verket ditt uten din tillatelse, kan du følge prosessen skissert her https://no.player.fm/legal.
0:00 Introduction
4:23 Insights into clonal hematopoiesis from the pioneering Framingham Heart Study
8:30 Linking clonal hematopoiesis to cancer and cardiovascular health
11:22 Interplay of germline and somatic variants in clonal expansion
17:20 How the rate of clonal expansion can provide insights into cancer and cardiovascular risk
19:00 How clonal hematopoiesis interplays with other orthogonal risk factors, including polygenic risk scores, and more established conventional heart health measures
21:00 Integration of genomic data in medical care, leading to the rise of preventative medicine
25:50 Insights into the Vanderbilt Genomics and Therapeutics Clinic
30:00 A dive into the Million Veterans Program, including the discovery of a modifier variant in the APOL1 gene related to kidney disease
44:05 How to differentiate the effects of modifier variants from risk variants in genetic studies
51:00 Individuals with APOL1 loss of function and its implications in kidney health
55:45 Closing remarks
179 episoder
MP3•Episoder hjem
Manage episode 393540661 series 2631947
Innhold levert av Sano Genetics. Alt podcastinnhold, inkludert episoder, grafikk og podcastbeskrivelser, lastes opp og leveres direkte av Sano Genetics eller deres podcastplattformpartner. Hvis du tror at noen bruker det opphavsrettsbeskyttede verket ditt uten din tillatelse, kan du følge prosessen skissert her https://no.player.fm/legal.
0:00 Introduction
4:23 Insights into clonal hematopoiesis from the pioneering Framingham Heart Study
8:30 Linking clonal hematopoiesis to cancer and cardiovascular health
11:22 Interplay of germline and somatic variants in clonal expansion
17:20 How the rate of clonal expansion can provide insights into cancer and cardiovascular risk
19:00 How clonal hematopoiesis interplays with other orthogonal risk factors, including polygenic risk scores, and more established conventional heart health measures
21:00 Integration of genomic data in medical care, leading to the rise of preventative medicine
25:50 Insights into the Vanderbilt Genomics and Therapeutics Clinic
30:00 A dive into the Million Veterans Program, including the discovery of a modifier variant in the APOL1 gene related to kidney disease
44:05 How to differentiate the effects of modifier variants from risk variants in genetic studies
51:00 Individuals with APOL1 loss of function and its implications in kidney health
55:45 Closing remarks
179 episoder
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