How can we, humans, look at our relationship to nature differently? In season three of Going Wild, on top of stories about animals, we invite you to journey through the entire ecological web — from the tiniest of life forms to apex predators — alongside the scientists, activists and adventurers who study it. Wildlife biologist and host Dr. Rae Wynn-Grant has been studying wild animals in their natural habitats all over the world for years. Our award-winning podcast takes you inside the hidde ...
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Innhold levert av Sano Genetics. Alt podcastinnhold, inkludert episoder, grafikk og podcastbeskrivelser, lastes opp og leveres direkte av Sano Genetics eller deres podcastplattformpartner. Hvis du tror at noen bruker det opphavsrettsbeskyttede verket ditt uten din tillatelse, kan du følge prosessen skissert her https://no.player.fm/legal.
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EP103: Gene Writing with Tessera Therapeutics CEO, Dr. Mike Severino
MP3•Episoder hjem
Manage episode 375003945 series 2631947
Innhold levert av Sano Genetics. Alt podcastinnhold, inkludert episoder, grafikk og podcastbeskrivelser, lastes opp og leveres direkte av Sano Genetics eller deres podcastplattformpartner. Hvis du tror at noen bruker det opphavsrettsbeskyttede verket ditt uten din tillatelse, kan du følge prosessen skissert her https://no.player.fm/legal.
In this episode, Patrick is joined by Dr. Mike Severino, CEO of Tessera Therapeutics and CEO-Partner of Flagship Pioneering. Join us as Mike walks us through Tessera’s approach to treating genetic diseases by rewriting bases, exons, or even whole genes with a novel approach called Gene Writing. 0:00 Intro 1:00 What prompted you to join Flagship Pioneering? 3:32 How is Flagship able to innovate and invent novel therapies in ways that Big Pharma companies may find difficult? 5:00 Introduction to gene writing and the role of Tessera Therapeutics 8:22 The current limitations and challenges of gene writing 10:22 Gene knockouts vs gene writing – which is more useful for genetic therapies? 12:30 Reasons why the liver the most commonly targeted organ for gene therapies 19:00 Lipid Nanoparticles and their role in gene writing 22:45 How do you guide mobile genetic elements to write genes in the intended location? 25:20 Development of gene writing technology since 2018 28:15 The implications of gene writing for diseases like PKU, Alpha-1 antitrypsin deficiency, sickle cell disease, and cancer 34:00 Next steps on the way to clinical trials 36:46 Using genomics and computational biology to guide measurable outcomes in drug discovery and development 40:15 Using gene writing to address rare developmental diseases 43:32 Closing remarks
…
continue reading
187 episoder
MP3•Episoder hjem
Manage episode 375003945 series 2631947
Innhold levert av Sano Genetics. Alt podcastinnhold, inkludert episoder, grafikk og podcastbeskrivelser, lastes opp og leveres direkte av Sano Genetics eller deres podcastplattformpartner. Hvis du tror at noen bruker det opphavsrettsbeskyttede verket ditt uten din tillatelse, kan du følge prosessen skissert her https://no.player.fm/legal.
In this episode, Patrick is joined by Dr. Mike Severino, CEO of Tessera Therapeutics and CEO-Partner of Flagship Pioneering. Join us as Mike walks us through Tessera’s approach to treating genetic diseases by rewriting bases, exons, or even whole genes with a novel approach called Gene Writing. 0:00 Intro 1:00 What prompted you to join Flagship Pioneering? 3:32 How is Flagship able to innovate and invent novel therapies in ways that Big Pharma companies may find difficult? 5:00 Introduction to gene writing and the role of Tessera Therapeutics 8:22 The current limitations and challenges of gene writing 10:22 Gene knockouts vs gene writing – which is more useful for genetic therapies? 12:30 Reasons why the liver the most commonly targeted organ for gene therapies 19:00 Lipid Nanoparticles and their role in gene writing 22:45 How do you guide mobile genetic elements to write genes in the intended location? 25:20 Development of gene writing technology since 2018 28:15 The implications of gene writing for diseases like PKU, Alpha-1 antitrypsin deficiency, sickle cell disease, and cancer 34:00 Next steps on the way to clinical trials 36:46 Using genomics and computational biology to guide measurable outcomes in drug discovery and development 40:15 Using gene writing to address rare developmental diseases 43:32 Closing remarks
…
continue reading
187 episoder
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