Show Me the Science is the new podcast from Washington University School of Medicine in St. Louis, Missouri. Our podcast features stories that highlight the latest in groundbreaking research, clinical care and education at Washington University.
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Newly approved drug may slow progression of Alzheimer’s
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In this episode, Washington University researchers discuss the Food and Drug Administration’s recent full approval of the drug Leqembi (lecanemab) and what it could mean to the future of Alzheimer’s disease treatments. The drug is approved for use in people with mild dementia from Alzheimer’s disease, but researchers at Washington University’s Char…
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Can psychedelic drugs help treat mental illness?
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In this episode, we discuss new research into psychedelic drugs as potential therapies for psychiatric illness. Several studies have suggested that drugs, such as psilocybin, may be useful in treating problems such as post-traumatic stress disorder, addiction and depression. Psychiatry researchers at Washington University School of Medicine in St. …
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In this episode, we hear from two physician-scientists who have been leaders in the U.S. effort to deal with two medical crises that emerged almost 40 years apart: HIV/AIDS and COVID-19. Anthony S. Fauci, MD, the recently retired director of the National Institute for Allergy and Infectious Diseases at the National Institutes of Health (NIH), spoke…
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Making connections through storytelling
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In this episode, we visit a recent event sponsored by the Becker Medical Library at the School of Medicine. Called “In Our Words: Connection,” the storytelling event brought together 12 faculty members, medical students, residents and fellows who told stories about how their lives have been affected by medicine as caregivers, those receiving care o…
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Maternal mortality rates are spiking. How can the trend be reversed?
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In this episode, we report on the disturbing spike in maternal mortality rates in recent years. Although rates of maternal death have long been higher in the U.S. than in other wealthy countries, the rate recently reached its highest level since 1965. The number of deaths of mothers has risen from 17.4 deaths per 100,000 births in 2018 to 20.1 deat…
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International effort aims to help those at risk for serious psychiatric illness
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In this episode, we report on a major international study involving psychiatry researchers from the School of Medicine who are working to identify causes and effects of the early stages of schizophrenia in young people — an illness characterized by significant changes in thoughts, feelings and behavior that may include a loss of contact with realit…
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Recognizing, caring for dementia patients in the emergency department
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In this episode, we head to the emergency department. Doctors in most emergency departments around the country are dealing with fewer COVID-19-positive patients than before, but they continue to be faced with a different epidemic of sorts: the 20% to 30% of patients with dementia-related cognitive issues who seek emergency care. As the U.S. populat…
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Brain-related issues can linger after patients recover from COVID-19
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In this episode, we learn more about one of the leading problems associated with long COVID-19. Those who have been infected with the virus are at increased risk for a range of neurological conditions in the first year after an infection. Research conducted at the School of Medicine and the Veterans Affairs St. Louis Health Care System has found th…
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Treating the whole patient all at once
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In this episode, we visit the team at the Washington University Living Well Center. It was launched to improve outcomes for patients with orthopedic issues. For example, if someone needs hip-replacement surgery, that person also can receive help losing weight, stopping smoking and taking other actions to make it more likely the outcome from their s…
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Updated boosters and progress toward a nasal vaccine
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As we get deeper into autumn and winter approaches, we discuss COVID-19 vaccines. New boosters have been developed to rev up the immune system not only to fight the original strain of the virus but also to boost the immune system against more recent omicron strains of SARS-CoV-2. In this episode, we discuss the boosters — now approved for use in ch…
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If you were coughing, running a fever and felt short of breath, what would you think? Those are common symptoms of COVID-19. But not everyone with such symptoms is infected with the virus. In this episode, we tell the story of a Michael Moffitt, a young man who grew up in St. Louis but was been working in the oil and gas fields of New Mexico. He go…
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New COVID-19 variants causing re-infections
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Infections and hospitalizations are rising again. During this latest wave of COVID-19 infections, many fully vaccinated people are getting sick, as are people who previously were sick with the virus, even those infected in the very recent past. The new strains of omicron — BA.4 and BA.5 — have stricken some well-known, fully vaccinated people, incl…
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Brain-computer interfaces connect activity in the brain to an external device by means of a computer. Research has shown it’s possible to use such interfaces to move robotic arms and perform other tasks. Almost 30 years ago, Washington University researcher Eric Leuthardt, MD, a professor of neurosurgery, demonstrated that he could hook electrodes …
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Long COVID-19 a lasting battle for many
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As many as 30% of those who get COVID-19 will continue to have problems in the weeks and months after their infections. Long COVID-19 is defined as a condition in which issues persist for at least three months. But for many, the difficulties last much longer. Extreme fatigue, shortness of breath and what many call brain fog lead the list of long-te…
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Pandemic fuels use of alcohol, opioids
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In this episode, we discuss issues that were problems long before anyone ever heard of COVID-19: alcohol use disorder and opioid overdose. Both seem to have gotten worse during the pandemic. Alcohol sales rose during the early days of lockdown, and they’ve remained high. Laura J. Bierut, MD, the Alumni Endowed Professor of Psychiatry, says another …
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As 'Show Me the Science' turns 2, we look back at 2 years of a pandemic
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But for this episode, we’re sticking with COVID-19. In 2020, when the pandemic shut down much of the country, our very first guest on “Show Me the Science” was Steven J. Lawrence, MD, a professor of medicine in the Division of Infectious Diseases. He also was our first guest of our second season of podcast episodes last year. And we’ve brought him …
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Long COVID can affect every organ system in the body
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The death toll isn’t the only staggering statistic from the first two years of the pandemic. What’s become increasing clear is that some COVID-19 patients don’t get well right away. Since the earliest days of the pandemic, we’ve heard of survivors who continue to experience shortness of breath, extreme fatigue, lingering difficulty with taste and s…
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Adjusting the nation's COVID-19 response
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With the pandemic death toll approaching 1 million people in the United States, Rochelle P. Walensky, MD, the director of the U.S. Centers for Disease Control and Prevention (CDC), and a Washington University alum, visited Washington University School of Medicine on March 2 and March 3, 2022. As part of the Department of Medicine’s weekly Grand Rou…
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Can we communicate more effectively about vaccines?
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More than 900,000 people in the United States have died of COVID-19, and over the last year, almost all of those deaths have been among unvaccinated people. Still, many people remain unvaccinated, and many say they are not sure whether they can trust the things public health officials say about COVID vaccines. Washington University infectious disea…
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With U.S. hospitals crowded with COVID-19 patients for almost two years, the pandemic’s relentlessness has pushed many doctors, nurses and other health-care professionals to the brink. Many have decided to leave the field or question whether to remain. Researchers at Washington University School of Medicine in St. Louis have launched a research pro…
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Highly contagious omicron is a roller coaster
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The omicron variant of SARS-CoV-2 arrived in the United States around Thanksgiving. Within a few weeks, it was the dominant variant in the country, and hospitals suddenly were crowded with COVID-19 patients again. More patients were hospitalized in the St. Louis region as the omicron wave hit than at any other time during the pandemic. The good new…
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When SARS-CoV-2 first arrived, it was as if a raging wildfire had been blown by a strong wind through dry, flammable timber. So says Ali Ellebedy, PhD, an immunologist at Washington University School of Medicine in St. Louis. As a population, he says, we were completely vulnerable to the virus because no one’s immune system had seen it before. In t…
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Hospitalized patients with COVID reach record levels
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Although there seems to be evidence that infections with the omicron variant of SARS-CoV-2 are somewhat milder, you wouldn’t know that from the number of COVID-19 patients in the hospital. A post-holiday spike in cases has seen the number of inpatients at Barnes-Jewish Hospital and St. Louis Children’s Hospital rise to levels higher than any seen s…
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The omicron variant of SARS-CoV-2 is here, but it’s the delta variant that has been driving a rapid increase in COVID-19 hospitalizations in recent weeks as people get out into the world more, antibody responses from vaccines wane, and families travel and gather in larger groups. As cases surge and hospitalizations increase, health-care workers are…
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A few weeks ago, no one had heard of the omicron variant of SARS-CoV-2. Since its recent discovery by scientists in South Africa, infections with the variant have been found in dozens of U.S. states and countries around the world. Scientists are scrambling to understand whether the new variant, which houses several mutations on the spike protein th…
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Over a million kids ages 5 to 11 have had the first dose of the COVID-19 vaccine, and a growing number of older people are getting booster shots. Although the official recommendation limits the booster to those over age 65, with weakened immune systems or who have jobs that put them at high risk for exposure to the novel coronavirus, that's expecte…
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COVID-19 has killed more than 5 million people around the world, with more than 740,000 dead in the United States. Although the virus is far more deadly in older people than in children, more than 650 kids have died of COVID-19 in the United States. Meanwhile, during the surge caused by the delta variant, hospitalizations of children increased five…
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Remaining resilient while the pandemic drags on
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Even as the numbers of COVID-19 cases around the country decline again, with cooler weather and people moving back indoors, we’re being warned about the possibility of another swing upward in cases. Such an increase would represent yet another wave of illness during this pandemic. And after all these months, the stress is getting to many people. Gr…
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Boosters? Vaccines for kids? Where do we stand heading toward winter?
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Recently, the federal government decided that vaccine booster shots will be made available for Americans 65 and older, those with compromised immune systems and others in high-risk jobs. In addition, Pfizer has submitted data asserting its vaccine is safe and effective for children ages 5-12. The next step could be an emergency use authorization fr…
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Shutdowns in COVID-19's early days helped St. Louis area avoid thousands of deaths
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In March 2020, the first cases of COVID-19 were reported in the St. Louis region, and health officials in St. Louis County and the city of St. Louis issued emergency orders to try to halt the virus’ spread. A new study from researchers at Washington University School of Medicine in St. Louis determined that those orders may have saved hundreds of l…
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Vaccines and COVID-19 infection generate protective antibodies, even against Delta
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It’s been a busy summer in the laboratory of Ali Ellebedy, PhD, an associate professor of pathology & immunology and of molecular microbiology at Washington University School of Medicine in St. Louis. Studying samples from patients with COVID-19 infections and others who have been vaccinated against the virus, he’s found hopeful signs in the immune…
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New threats from highly contagious delta variant
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As patients infected with the delta variant of the COVID-19 virus fill hospitals in parts of Missouri, and the virus spreads new infections around the country, Washington University data scientists and infectious diseases specialists are urging people to mask up again, regardless of vaccination status. The researchers say that although vaccination …
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Pregnant patients who get COVID-19 have much worse outcomes than women who don’t get infected. They are three times as likely to end up in intensive care, three times as likely to need a ventilator to help them breathe and twice as likely to die. Ebony Boyce Carter, MD, an assistant professor of obstetrics & gynecology, has delivered babies through…
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Vaccinating kids against COVID-19 likely to enhance school safety
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Whether and how children can return to classrooms has been hotly debated during the past year. Requiring teachers and students to wear masks, spreading out kids in classrooms and preventing students and staff from coming to school when sick has made most schools safe. With many teachers now vaccinated and more children now eligible, it’s expected t…
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What to make of CDC's new masking guidelines
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After recently announcing that vaccinated people could safely take off their masks outdoors and gather in small groups with other vaccinated people indoors, the U.S. Centers for Disease Control and Prevention (CDC) next decided that vaccinated people no longer need to wear masks indoors either. The new guidelines caught many by surprise, but Willia…
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Pandemic contributing to uptick of mental health problems in kids
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Infections with the virus that causes COVID-19 are not the only cause of pandemic-related hospitalizations. Although children tend to be at lower risk of COVID-19, the number of kids with mental health and behavioral problems has exploded during the pandemic, driving an increase in pediatric hospital admissions nationwide. Stressors associated with…
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A year later, scientists recall their efforts to jumpstart research into the mysterious new coronavirus
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Even before the first case of COVID-19 was reported in the United States, Michael S. Diamond, MD, PhD, the Herbert S. Gasser Professor of Medicine, started setting the stage with Sean Whelan, PhD, the Marvin A. Brennecke Distinguished Professor of Molecular Microbiology, for scientists at the university to study the virus. Whelan had just arrived i…
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After a year of COVID-19, vaccines making life better but it’s not over
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When we launched this podcast in March 2020, our first guest was a doctor who had spent years planning responses to epidemics, bioterrorism and other disasters. Last March, Steven J. Lawrence, MD, a professor of medicine in the Division of Infectious Diseases, told us what he thought might happen as the pandemic progressed. He worried about whether…
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Loss of smell, heart problems common symptoms for long-haulers
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In the year since COVID-19 infections first appeared in the United States, a few things have become clear. One is that many who get sick don’t recover quickly. Even those who don’t have to be hospitalized can experience symptoms that linger. Called long-haulers, these individuals suffer from a variety of issues such as shortness of breath, abnormal…
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Avoiding burnout and tending to mental health as the pandemic runs into a second year
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It’s been a year since the first COVID-19 cases started appearing in the United States, and during this span, many people have been living with the stress of trying to work from home while simultaneously trying to help their kids attend online school. Essential workers haven’t had the safety of home, having to continue working in grocery stores, an…
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Improving health messaging in fight to slow COVID-19
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For the past year, we’ve heard about the importance of wearing masks, avoiding crowds, maintaining physical distance and regularly washing our hands. All of us have been asked to take simple steps to protect ourselves and those around us. But nothing is simple when you have to do it every day for months, particularly while receiving mixed messages …
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Vaccines have arrived but COVID-19 treatments progressing much more slowly
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COVID-19 vaccine development has been rapid and successful. Two vaccines that report more than 90% efficacy against the virus already are in use, with approval of more vaccines expected in the coming weeks. Meanwhile, the development of treatments for those infected with the virus has been slower. Only one drug, the steroid dexamethasone, has been …
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Drug companies are reporting eye-popping success rates in clinical trials of their vaccines to prevent COVID-19. It’s possible the first people in the U.S. could begin getting shots before the end of the year. In this episode, we’ll hear about the amazing pace of vaccine development, as well as Washington University’s role in vaccine research, from…
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Preparing for winter and the holidays under the shadow of COVID-19
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Winter is coming, and the pandemic is intensifying in most of the country, with numbers of COVID-19 cases setting records almost daily, cold weather approaching and people moving activities indoors. In addition, college students who have been away at school for the last few months will return home soon, and extended families are trying to figure ou…
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Preventing COVID-19 among unhoused people
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Testing, social distancing, wearing masks and regular hand washing are among the tools recommended to limit the spread of the SARS-CoV-2 virus that causes COVID-19. But achieving such practices can be challenging for people who don’t have homes and often must eat and sleep in places with other people. Experts from Washington University School of Me…
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The making of a fast, accurate saliva test for COVID-19
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Since the start of the COVID-19 pandemic, health officials have talked about the need for better, faster and more frequent testing. Recently, researchers at Washington University School of Medicine in St. Louis developed a saliva test that can detect the SARS-CoV-2 virus without inserting a nasopharyngeal swab into the nose or throat. The saliva te…
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COVID-19, social media and those with intellectual and developmental disabilities
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The pandemic is affecting everyone, but the stresses it causes are particularly rough for those with intellectual and developmental disabilities and their families. Providing effective education to such children and getting services to those who need help in their homes is typically complex, but those issues are even more difficult in the face of C…
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Where does life in the U.S. stand six months into the pandemic?
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It’s possible some people may have been infected earlier, but the first COVID-19 diagnoses in the U.S. occurred in late January. Since then, testing failures, partisan political debates, conspiracy theories and desperate searches for effective treatments have characterized the pandemic response in the United States. However, through all of the nois…
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Can boosting the immune system, rather than suppressing it, work against COVID-19?
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New research from scientists at Washington University School of Medicine in St. Louis suggests that the immune systems of COVID-19 patients can’t do enough to protect them from the virus. A popular theory has it that patients’ immune systems get so revved up fighting the virus that, after several days, a so-called cytokine storm ensues, resulting i…
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Folding@home enlists computers to ID COVID-19 treatment targets
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The crowdsourced supercomputing project Folding@home harnesses the combined processing power of millions of computers whose owners download software and run simulations to model how proteins move and fold. Now, in response to the COVID-19 pandemic, individuals, universities companies, even the Spanish soccer league La Liga, have joined forces to mo…
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