AJP 61 | Sjur Even Aunmo — Fikk sparken for å snakke om bivirkninger

Antijantepodden

Allmennlege Sjur Even Aunmo fikk sparken som fastlegevikar fordi han fortalte pasienter at COVID-19-vaksinen kan gi bivirkninger. Dette er noe han plikter å gjøre ifølge Pasient- og brukerrettighetsloven § 4. Aunmo har satt seg grundig inn i forskningen på disse vaksinene, og påpeker at de for det første er eksperimentelle på dette stadiet. Videre er det Pfizer selv som har finansiert sin studie, en ansatt fikk sparken fordi hun varslet om at blindingen (anonymiseringen) var brutt, personer har blitt tatt ut av studien uten at det er oppgitt noen god grunn og rådataene for studien er ikke offentliggjort. Selv har han sett flere bivirkninger, som kraftige menstruasjonsblødninger, hjerteproblemer og alvorlige nevrologiske bivirkninger. Han frykter at underrapportering kan medføre at bivirkningstallene fra Statens legemiddelverk er for lave.
KILDER:
› COVID-19
• https://clinicaltrials.gov/ct2/show/NCT04368728
• https://clinicaltrials.gov/ct2/show/NCT04470427
• Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine
• Efficacy of the mRNA-1273 SARS-CoV-2 Vaccine at Completion of Blinded Phase
• https://covid-nma.com/vaccines/variants/
• https://covid-nma.com/vaccines/index.php?search_by=1&search_input=1273&submit=Validate#moteur_recherche
• How significant is the Ventavia scandal?
• Covid-19: Researcher blows the whistle on data integrity issues in Pfizer’s vaccine trial
• CDC-vurdering av Modernas studie
• https://www.bmj.com/company/newsroom/editors-call-for-covid-19-vaccine-and-treatment-data-to-be-available-for-public-scrutiny/
• https://www.nrk.no/norge/norges-forste-koronavaksine-settes-1.15304159, lest 20.3.22
• https://tidsskriftet.no/2021/05/originalartikkel/dodsfall-i-sykehjem-etter-covid-19-vaksine
◦ https://www.fhi.no/hn/helseregistre-og-registre/dodsarsaksregisteret/tall-for-covid-19-assosierte-dodsfall-i-dodsarsaksregisteret-i-2020/
◦ https://legemiddelverket.no/Documents/Bivirkninger%20og%20sikkerhet/Rapporter%20og%20oversikter/Koronavaksiner/20211028%20Rapport%20over%20meldte%20bivirkninger%20av%20koronavaksine.pdf
◦ Surveillance for safety after immunization; vaccine adverse event reporting system (VAERS) - United States 1991-2001
◦ Mandatory Reporting of Infectious Diseases by Clinicians
◦ Myopericarditis after vaccination, Vaccine Adverse Event Reporting System (VAERS), 1990–2018
◦ https://www.nrk.no/livsstil/_-en-medisinsk-katastrofe-1.10880384
◦ https://legemiddelverket.no/nyheter/bivirkninger-av-vaksiner-hva-lerte-vi-av-pandemien-i-2009#ble-det-meldt-noen-d%C3%B8dsfall?
◦ The illusion of evidence based medicine
‧ Amerikanske Centers for Disease Control om underrapportering
‧ Studie fra det medisinske tidsskriftet JAMA om underrapportering
‧ Studie fra det medisinske tidsskriftet Vaccine om underrapportering
‧ Fra det amerikanske registrerings-systemet VAERS om deres system
‧ Randomised Clinical Trials of COVID-19 Vaccines: Do Adenovirus-Vector Vaccines Have Beneficial Non-Specific Effects?
‧ Lancet 2022. Samlestudie RCT. Obs: Preprrint, ikke fagfallevurdert enda. Signifikant og stor forskjell mellom Pfizer/Moderna og svekket-virus-vaksiner.
› FETT
• Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis
• Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73)
• Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease
• The effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials
• Saturated Fats and Health: A Reassessment and Proposal for Food-Based Recommendations: JACC State-of-the-Art Review
• http://dx.doi.org/10.1136/openhrt-2014-000196
• Fat or fiction: the diet-heart hypothesis | BMJ Evidence-Based Medicine
• https://www.mn.uio.no/ibv/tjenester/kunnskap/plantefys/leksikon/h/herdet-fett.html
• 4-Hydroxynonenal-Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease
• https://doi.org/10.1016/j.freeradbiomed.2006.07.021
◦ Dietary stearic acid regulates mitochondria in vivo in humans - Nature Communications
◦ 33.9 10.17140/AFTNSOJ-1-123 Oxidation of Polyunsaturated Fatty Acids and its Impact on Food Quality and Human Health
◦ Dietary oxidized n-3 PUFA induce oxidative stress and inflammation: role of intestinal absorption of 4-HHE and reactivity in intestinal cells
◦ Effect of the Type of Frying Culinary Fat on Volatile Compounds Isolated in Fried Pork Loin Chops by Using SPME-GC-MS
› STATINER
• BMJ RCT sysrew/meta Statins for the primary prevention of cardiovascular disease: an overview of systematic reviews
• The effect of statins on average survival in randomised trials, an analysis of end point postponement
• JAMA RCT-meta 2010 - Statins and All-Cause Mortality in High-Risk Primary Prevention: A Meta-analysis of 11 Randomized Controlled Trials Involving 65 229 Participants
• https://www.felleskatalogen.no/medisin/lipitor-upjohn-eesv-pfizer-560999
• https://www.felleskatalogen.no/medisin/zocor-organon-565655
• https://www.legemiddelhandboka.no/L8.15.1/Statiner
• Statins - a call for transparent data - The BMJ
• Statin Use and Risk of Diabetes Mellitus in Postmenopausal Women in the Women's Health Initiative
› KJØTT
• Effect of Lower Versus Higher Red Meat Intake on Cardiometabolic and Cancer Outcomes A Systematic Review of Randomized Trials
• Total red meat intake of ≥0.5 servings/d does not negatively influence cardiovascular disease risk factors: a systemically searched meta-analysis of randomized controlled trials
› KOLESTEROL
• Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review
• Inborn coagulation factors are more important cardiovascular risk factors than high LDL-cholesterol in familial hypercholesterolemia
• PMID: 18277343 ApoB/ApoA1 ratio and subclinical atherosclerosis
◦ Cigarette smoking renders LDL susceptible to peroxidative modification and enhanced metabolism by macrophages
◦ Cigarette Smoking Potentiates Endothelial Dysfunction of Forearm Resistance Vessels in Patients With Hypercholesterolemia: Role of Oxidized LDL
◦ Passive Smoking Induces Atherogenic Changes in Low-Density Lipoprotein
◦ Smoking and smoking cessation—The relationship between cardiovascular disease and lipoprotein metabolism: A review
◦ Smoking and Cardiovascular Disease
◦ LDL biochemical modifications: a link between atherosclerosis and aging
◦ Association Between Circulating Oxidized LDL and Atherosclerotic Cardiovascular Disease: A Meta-analysis of Observational Studies
› KARBOHYDRAT
• https://www.helsedirektoratet.no/rapporter/anbefalinger-om-kosthold-ernaering-og-fysisk-aktivitet/Anbefalinger%20om%20kosthold%20ern%C3%A6ring%20og%20fysisk%20aktivitet.pdf/_/attachment/inline/2f5d80b2-e0f7-4071-a2e5-3b080f99d37d:2aed64b5b986acd14764b3aa7fba3f3c48547d2d/Anbefalinger%20om%20kosthold%20ern%C3%A6ring%20og%20fysisk%20aktivitet.pdf
› DIABETES
• JAMA WMI 2006Low-Fat Dietary Pattern and Risk of Cardiovascular DiseaseThe Women's Health Initiative Randomized Controlled Dietary Modification Trial – se side 661, økt hjerte/kar-risk sfa. Lavfett-diett
• AmJourClinNutr WMI 2011 Effects of a low-fat dietary intervention on glucose, insulin, and insulin resistance in the Women’s Health Initiative (WHI) Dietary Modification trial
• AOCS Lipids (lavranket journal) Carbohydrate Restriction has a More Favorable Impact on the Metabolic Syndrome than a Low Fat Diet
• Small Dense Low-Density Lipoprotein-Cholesterol Concentrations Predict Risk for Coronary Heart Disease- ArtThromVas prospektiv kohort
• Glycation as an atherogenic modification of LDL : Current Opinion in Lipidology
• Glycosylated low density lipoprotein is more sensitive to oxidation: implications for the diabetic patient?
• Loss of Endothelial Glycocalyx During Acute Hyperglycemia Coincides With Endothelial Dysfunction and Coagulation Activation In Vivo
› DIABETES-DEMENS
• AgeingResearchRewiew 2019 sysrew/meta 144 prospektive studier – 58 % økt risiko demens
• Int. Med. Journ. 2012 meta-analyse av prospektive kohorter dia-demens-risk 51 % økning demens
• Lancet Neurology 2006, sysrew lavere evidensgrad. Risk of dementia in diabetes mellitus: a systematic review
• Diabetes mellitus and the risk of dementia - The Rotterdam Study – prospektiv kohort
• JDST 2008 Alzheimer's Disease is Type 3 Diabetes—Evidence Reviewed
• MDPI 2015 Evaluating the Association between Diabetes, Cognitive Decline and Dementia
• Ketone Bodies Promote Amyloid-β1–40 Clearance in a Human in Vitro Blood–Brain Barrier Model - 2020
• Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implication - 2018
• APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline - 2020
› HJERTE- OG KAR-SYKDOM
• 10.1001/jamacardio.2020.7073 Association of Lipid, Inflammatory, and Metabolic Biomarkers With Age at Onset for Incident Coronary Heart Disease in Women
› PLANTE-ANTINÆRINGSSTOFF OG VERN
• Food Chemistry 2008 Bioaccessibility of Ca, Mg, Mn and Cu from whole grain tea-biscuits: Impact of proteins, phytic acid and polyphenols
• Phytate in foods and significance for humans: food sources, intake, processing, bioavailability, protective role and analysis. Mol Nutr Food Res. 2009 Sep;53 Suppl 2:S330-75.
• Oxalate content of foods and its effect on humans
• Lectins as plant defense proteins
• Effects of wheat germ agglutinin on human gastrointestinal epithelium: Insights from an experimental model of immune/epithelial cell interaction
• Ingestion of subthreshold doses of environmental toxins induces ascending Parkinsonism in the rat
• Identification of intact peanut lectin in peripheral venous blood
• Do dietary lectins cause disease? BMJ
• Lectin binding of endometrium in women with unexplained infertility
• Changes in organs and tissues induced by feeding of purified kidney bean (Phaseolus vulgaris) lectins
• Insecticidal Activity of Plant Lectins and Potential Application in Crop Protection
• Bound Lectins that Mimic Insulin Produce Persistent Insulin-Like Activities
• Contribution of leptin receptor N-linked glycans to leptin binding
• Potato lectin activates basophils and mast cells of atopic subjects by its interaction with core chitobiose of cell-bound non-specific immunoglobulin E
• <918::AID-IMMU918>3.0.CO;2-T Dietary lectins can induce in vitro release of IL-4 and IL-13 from human basophils
• Secondary Oxalate Nephropathy: A Systematic Review
• The effect of tea on iron absorption
• PMID: 1862 Disler PB, Lynch SR, Torrance JD, et al. The mechanism of the inhibition of iron absorption by tea. The South African Journal of Medical Sciences. 1975 ;40(4):109-116.
• Effects of saponins and glycoalkaloids on the permeability and viability of mammalian intestinal cells and on the integrity of tissue preparationsin vitro
• The biological action of saponins in animal systems: a review
• Small Amounts of Gluten in Subjects With Suspected Nonceliac Gluten Sensitivity: A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial
◦ Obs: Kapsler brukt i studien ble supplert av legemiddelfirmaet Giuliani, som lager glutenfritt brød.
› LEKK TARM
• Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines
• Gliadin Induces an Increase in Intestinal Permeability and Zonulin Release by Binding to the Chemokine Receptor CXCR3
• AmJourClinNu 2009 Cancer incidence in vegetarians: results from the European Prospective Investigation into Cancer and Nutrition (EPIC-Oxford)
• FODMAP diet modulates visceral nociception by lipopolysaccharide-mediated intestinal inflammation and barrier dysfunction
• 73.3 10.12688/f1000research.20510.1 All disease begins in the (leaky) gut: role of zonulin-mediated gut permeability in the pathogenesis of some chronic inflammatory diseases
› LAVKARB
• Effects of Low-Carbohydrate vs Low-Fat Diets on Weight Loss and Cardiovascular Risk Factors
• BritJourNutr 2013 RCT-meta Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials
• AnnIntMed 2004 A Low-Carbohydrate, Ketogenic Diet versus a Low-Fat Diet To Treat Obesity and Hyperlipidemia: A Randomized, Controlled Trial
• JAMAIntMed A Randomized Trial of a Low-Carbohydrate Diet vs Orlistat Plus a Low-Fat Diet for Weight Loss
• NEJM RCT 2006 A Low-Carbohydrate as Compared with a Low-Fat Diet in Severe Obesity
• Short-term effects of severe dietary carbohydrate-restriction advice in Type 2 diabetes—a randomized controlled trial
• Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: randomized trial
• Effects of a low-carbohydrate diet on weight loss and cardiovascular risk factor in overweight adolescents
• Comparison of the Atkins, Zone, Ornish, and LEARN Diets for Change in Weight and Related Risk Factors Among Overweight Premenopausal WomenThe A TO Z Weight Loss Study: A Randomized Trial
• Efficacy and Safety of a High Protein, Low Carbohydrate Diet for Weight Loss in Severely Obese Adolescents
• Long-Term Effects of a Novel Continuous Remote Care Intervention Including Nutritional Ketosis for the Management of Type 2 Diabetes: A 2-Year Non-randomized Clinical Trial
› FRUKTOSE
• JourHepatology 2021 Fructose- and sucrose- but not glucose-sweetened beverages promote hepatic de novo lipogenesis: A randomized controlled trial
• Effects of fructose restriction on liver steatosis (FRUITLESS); a double-blind randomized controlled trial
› KETOGENISITET/KREFT
• https://oslo-universitetssykehus.no/behandlinger/pet-undersokelse
• https://stanfordhealthcare.org/medical-tests/p/pet-scan/what-to-expect.html
• https://www.sciencedirect.com/topics/medicine-and-dentistry/warburg-effect
• The Warburg Effect: How Does it Benefit Cancer Cells?
• NutrCanc 2019 Feasibility, Safety, and Beneficial Effects of MCT-Based Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Trial Study
• Dietary Glycemic Load and Cancer Recurrence and Survival in Patients with Stage III Colon Cancer: Findings From CALGB 89803
• Ketogenic diet in cancer therapy
› IATROGEN SKADE
• https://tidsskriftet.no/2000/10/kronikk/uheldige-hendelser-i-helsetjenesten-forebygging-og-handtering
Last ned episoden
Innspilt: 2022-05-02
Publisert: 2022-05-22
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