Histamine & Burnout: The Connection with Will Cole

The Girlfriend Doctor w/ Dr. Anna Cabeca

What’s really behind your fatigue and brain fog? Ever feel like your body’s sending you an SOS, but you’re not sure what it’s trying to say? I sit down with Dr. Will Cole, a leading Functional Medicine Expert, to chat about two health issues that often fly under the radar: histamine intolerance and burnout. We talk about how these sneaky culprits can mess with your energy, focus, and even your digestion—especially during midlife or perimenopause. If you’ve been feeling “off” and can’t quite put your finger on why, this is a conversation you don’t want to miss.

Dr. Will doesn’t just share the science—he gives some seriously practical tips to help you feel better. We get into why gut health is such a big deal for managing histamine levels and what to do if you’re feeling stuck in a cycle of exhaustion. Burnout is also part of our conversation, and you’ll be surprised at how it’s not always tied to laziness—but it’s your body’s way of waving a red flag. Dr. Will shares simple, doable strategies like breathwork and mindfulness to help you reset and feel like yourself again.

And by the way, if you’re struggling with low energy, low libido, hormone imbalances, or menopausal symptoms, you’ve got to try my Mighty Maca Plus! My clients have called it a “godsend”. Head over to dranna.com/drinkmaca to give it a try—and experience the difference!

Key Timestamps:

[00:00:00] Introduction.

[00:01:44] Histamine intolerance in midlife.

[00:04:57] Histamine intolerance and hormones.

[00:07:29] Histamine intolerance symptoms and causes.

[00:11:28] Histamine intolerance management strategies.

[00:16:50] Burnout versus laziness.

[00:19:17] Nervous system dysregulation explained.

[00:21:56] Vagal tone stimulation practices.

[00:27:30] What breathwork is best to practice?

[00:29:58] Cold plunging for those with histamine intolerance.

Memorable Quotes:

"Not to say that perimenopause is causing histamine intolerance, but it can be certainly be gasoline on the fire for an already tempestuous immune system." [00:06:29] – Dr. Will Cole

"The right type of breathwork or the right type of medication for you is the one that you can stay consistent with that is conducive and congruent to your healing." [00:27:58] – Dr. Will Cole

Links Mentioned:

Keto Green Shake: https://dranna.com/drinkmaca

Connect with Dr. Will Cole:

Website: https://drwillcole.com/

Instagram: https://www.instagram.com/drwillcole

Podcast: https://drwillcole.com/podcast

Connect with Dr. Anna Cabeca:

Website: https://drannacabeca.com/pages/show

Instagram: https://www.instagram.com/thegirlfrienddoctor/

YouTube: https://www.youtube.com/@thegirlfrienddoctor

TikTok: https://www.tiktok.com/@drannacabeca

Produced by Evolved Podcasting: www.evolvedpodcasting.com